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- W2010560930 abstract "Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are <TEX>$Ca^{2+}$</TEX>-activated <TEX>$Ca^{2+}$</TEX>-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases." @default.
- W2010560930 created "2016-06-24" @default.
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- W2010560930 date "2015-01-31" @default.
- W2010560930 modified "2023-10-14" @default.
- W2010560930 title "Physiological functions of the TRPM4 channels via protein interactions" @default.
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- W2010560930 doi "https://doi.org/10.5483/bmbrep.2015.48.1.252" @default.
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