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- W2010561737 abstract "Low-grade irritants settling upon the alveolar surface, if not adequately diluted or removed by the alveolar clearance mechanism, cause an inflammatory reaction of the alveolar membrane. The perivascular interstitial tissues are not initially involved. The alveolar membrane is the target tissue and its inflammatory response consists of a proliferation of alveolar cells with associated supporting reticulin stroma which have become heaped upon the alveolar surface and which remain an integral part of the alveolar wall, thickening the latter. This inflammatory response is properly designated as a chronic interstitial pneumonitis and is initially qualitatively similar for a wide range of low-grade chronic irritants. Chronic interstitial pneumonitis, a reversible lesion in its early form because it contains little or no collagen, may be focal or diffuse. Although the pneumonitis may develop features in its subsequent evolution that are more or less characteristic of the particular causative irritant, relatively few of the latter can be identified by such special features. Chronic interstitial pneumonitis, particularly that caused by dusts, is commonly clinically silent unless a major portion of the lung is affected which has seriously reduced the pulmonary reserve." @default.
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- W2010561737 date "1962-02-01" @default.
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- W2010561737 title "The Alveolar Membrane as a Target Tissue: Morphologic Aspects" @default.
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- W2010561737 doi "https://doi.org/10.1378/chest.41.2.169" @default.
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