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• W2010564515 abstract "Blanchard, R. J., J. N. Nikulina, R. R. Sakai, C. McKittrick, B. McEwen and D. C. Blanchard. Behavioral and endocrine change following chronic predatory stress. Physiol Behav 63(4) 561–569, 1998. Adult male rats showed very high levels of crouching when exposed to a cat, with suppression of the nondefensive behaviors (e.g., lying, locomotion, rearing) that were shown by toy cat-exposed controls. The crouching of cat-exposed rats declined slightly but reliably with increasing time within daily 60-min exposure sessions. However, the lack of a reliable cat-exposure × days interaction for crouching over the 20 days of testing indicated minimal habituation of the rats’ defensive response to the cat over this exposure schedule, although rat and cat were separated by a wire mesh screen, precluding contact and pain. Following the 20th day of exposure, cat-exposed rats showed reliably higher basal plasma corticosterone levels, suggesting a lack of habituation of this stress-linked response as well. Adrenal weights were also higher and thymus weights lower in these animals compared with controls, while spleen and testes weights and testosterone levels were not reliably different. Of the 13 cat-exposed subjects, 6 (and a single control) failed to show a 10 μg/mL corticosterone (CORT) increase in response to an acute restraint stressor. In 3 of these 6 cat-exposed rats, the failure to meet this criterion was attributable to a low level of CORT following restraint, suggesting failure of the normal CORT surge to the acute restraint stressor. These findings of organ weight changes, enhanced basal CORT, and reduced CORT response to stress in a subgroup of animals are similar to many of the phenomena obtained with other intense, chronic stressors such as subordination, and suggest that repeated predator exposure produces a pattern of intense behavioral and endocrine response that is very slow to habituate. Because it is a natural stressor for both male and female subjects, and one for which pain and even handling of the subject is unnecessary, cat exposure may provide a particularly relevant and adaptable paradigm for research involving analysis of gender effects on the stress response." @default.
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• W2010564515 date "1998-02-01" @default.
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• W2010564515 title "Behavioral and Endocrine Change Following Chronic Predatory Stress" @default.
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• W2010564515 doi "https://doi.org/10.1016/s0031-9384(97)00508-8" @default.
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