FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010568588> ?p ?o ?g. }

• W2010568588 endingPage "1640" @default.
• W2010568588 startingPage "1632" @default.
• W2010568588 abstract "Well-differentiated neuroendocrine tumors including pancreatic endocrine tumors and carcinoid tumors are uncommon neoplasms that have site-specific differences in clinicopathological features, clinical course and genetic alterations. The epigenetic alterations in these tumors are not well characterized. We therefore compared methylation of the RAS-association domain family 1, isoform A (RASSF1A), p14, p16 and O6-methyl-guanine methyltransferase genes in neuroendocrine tumors from 47 patients including 16 pancreatic, 15 nonileal and 16 ileal neuroendocrine tumors. Methylation of the RASSF1A gene was present in 57% of tumors, p14 in 49%, p16 in 26% and O6-methyl-guanine methyltransferase in 13% of tumors. Ileal neuroendocrine tumors lacked methylation of O6-methyl-guanine methyltransferase gene (P=0.04). RASSF1A methylation was associated with histopathologic type of tumors (P=0.03) and lymph node metastasis (P=0.004), and p16 methylation with older patient age (P=0.002) and liver metastasis (P=0.04). Two or more genes were methylated in 53% of tumors, one gene was methylated in 30% of tumors, and all four genes were unmethylated in 17% of tumors. Methylation of one or more gene was associated with older age of patients (P=0.01), and methylation of two or more genes was associated with liver metastasis (P=0.044). Our study shows that in neuroendocrine tumors epigenetic alterations vary by tumor subsite and clinicopathologic features, including age of onset, histopatholoic type and metastasis status." @default.
• W2010568588 created "2016-06-24" @default.
• W2010568588 creator A5002209179 @default.
• W2010568588 creator A5043534982 @default.
• W2010568588 creator A5048355915 @default.
• W2010568588 creator A5055589818 @default.
• W2010568588 creator A5057453487 @default.
• W2010568588 creator A5059484239 @default.
• W2010568588 creator A5078636533 @default.
• W2010568588 creator A5088389768 @default.
• W2010568588 date "2005-12-01" @default.
• W2010568588 modified "2023-10-11" @default.
• W2010568588 title "Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis" @default.
• W2010568588 cites W1504197144 @default.
• W2010568588 cites W1571505119 @default.
• W2010568588 cites W1971863507 @default.
• W2010568588 cites W1973812603 @default.
• W2010568588 cites W1977706798 @default.
• W2010568588 cites W1985967354 @default.
• W2010568588 cites W1990509102 @default.
• W2010568588 cites W2011739365 @default.
• W2010568588 cites W2021527895 @default.
• W2010568588 cites W2026883093 @default.
• W2010568588 cites W2029080338 @default.
• W2010568588 cites W2036825872 @default.
• W2010568588 cites W2049085719 @default.
• W2010568588 cites W2066848701 @default.
• W2010568588 cites W2069723916 @default.
• W2010568588 cites W2084793761 @default.
• W2010568588 cites W2084891010 @default.
• W2010568588 cites W2087457210 @default.
• W2010568588 cites W2088985926 @default.
• W2010568588 cites W2113459016 @default.
• W2010568588 cites W2128146359 @default.
• W2010568588 cites W2143578264 @default.
• W2010568588 cites W2143917018 @default.
• W2010568588 cites W2148747232 @default.
• W2010568588 doi "https://doi.org/10.1038/modpathol.3800490" @default.
• W2010568588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16258509" @default.
• W2010568588 hasPublicationYear "2005" @default.
• W2010568588 type Work @default.
• W2010568588 sameAs 2010568588 @default.
• W2010568588 citedByCount "94" @default.
• W2010568588 countsByYear W20105685882012 @default.
• W2010568588 countsByYear W20105685882013 @default.
• W2010568588 countsByYear W20105685882014 @default.
• W2010568588 countsByYear W20105685882015 @default.
• W2010568588 countsByYear W20105685882016 @default.
• W2010568588 countsByYear W20105685882017 @default.
• W2010568588 countsByYear W20105685882018 @default.
• W2010568588 countsByYear W20105685882019 @default.
• W2010568588 countsByYear W20105685882020 @default.
• W2010568588 countsByYear W20105685882021 @default.
• W2010568588 countsByYear W20105685882022 @default.
• W2010568588 countsByYear W20105685882023 @default.
• W2010568588 crossrefType "journal-article" @default.
• W2010568588 hasAuthorship W2010568588A5002209179 @default.
• W2010568588 hasAuthorship W2010568588A5043534982 @default.
• W2010568588 hasAuthorship W2010568588A5048355915 @default.
• W2010568588 hasAuthorship W2010568588A5055589818 @default.
• W2010568588 hasAuthorship W2010568588A5057453487 @default.
• W2010568588 hasAuthorship W2010568588A5059484239 @default.
• W2010568588 hasAuthorship W2010568588A5078636533 @default.
• W2010568588 hasAuthorship W2010568588A5088389768 @default.
• W2010568588 hasBestOaLocation W20105685881 @default.
• W2010568588 hasConcept C104317684 @default.
• W2010568588 hasConcept C121608353 @default.
• W2010568588 hasConcept C134018914 @default.
• W2010568588 hasConcept C142724271 @default.
• W2010568588 hasConcept C150194340 @default.
• W2010568588 hasConcept C190727270 @default.
• W2010568588 hasConcept C2779013556 @default.
• W2010568588 hasConcept C2779066768 @default.
• W2010568588 hasConcept C33288867 @default.
• W2010568588 hasConcept C41091548 @default.
• W2010568588 hasConcept C502942594 @default.
• W2010568588 hasConcept C54355233 @default.
• W2010568588 hasConcept C71924100 @default.
• W2010568588 hasConcept C86803240 @default.
• W2010568588 hasConcept C91965660 @default.
• W2010568588 hasConceptScore W2010568588C104317684 @default.
• W2010568588 hasConceptScore W2010568588C121608353 @default.
• W2010568588 hasConceptScore W2010568588C134018914 @default.
• W2010568588 hasConceptScore W2010568588C142724271 @default.
• W2010568588 hasConceptScore W2010568588C150194340 @default.
• W2010568588 hasConceptScore W2010568588C190727270 @default.
• W2010568588 hasConceptScore W2010568588C2779013556 @default.
• W2010568588 hasConceptScore W2010568588C2779066768 @default.
• W2010568588 hasConceptScore W2010568588C33288867 @default.
• W2010568588 hasConceptScore W2010568588C41091548 @default.
• W2010568588 hasConceptScore W2010568588C502942594 @default.
• W2010568588 hasConceptScore W2010568588C54355233 @default.
• W2010568588 hasConceptScore W2010568588C71924100 @default.
• W2010568588 hasConceptScore W2010568588C86803240 @default.
• W2010568588 hasConceptScore W2010568588C91965660 @default.
• W2010568588 hasIssue "12" @default.
• W2010568588 hasLocation W20105685881 @default.
• W2010568588 hasLocation W20105685882 @default.

• next