FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010568711> ?p ?o ?g. }

• W2010568711 endingPage "238" @default.
• W2010568711 startingPage "231" @default.
• W2010568711 abstract "The effects of dietary administration of 1H, 1H, 2H, 2H-perfluorodecanol (8-2 telomer alcohol), on peroxisome proliferation in the liver of mice were studied. Male ddY mice were fed on a diet containing 8-2 telomer alcohol at concentrations of 0, 0.025, 0.05, 0.1, and 0.2% (w/w) for 7, 14, 21, and 28 days. These treatments with 8-2 telomer alcohol caused liver enlargement in a dose- and duration-dependent manner. Peroxisome proliferation in the liver of mice was confirmed by electron microscopic examination. Peroxisomal acyl-CoA oxidase was induced by these treatments with 8-2 telomer alcohol in a dose- and time-dependent manner. The concentration of perfluorooctanoic acid (PFOA) and related compounds were determined in the liver and plasma, since PFOA had been shown to be a possible metabolite of 8-2 telomer alcohol and to cause significant peroxisome proliferation in rodents. Five metabolites, namely, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), 2H, 2H-perfluorodecanoic acid (8-2 telomer acid), and two unidentified metabolites, were present in the liver and serum. PFOA was confirmed to be accumulated in the liver of mice following the administration of 8-2 telomer alcohol in a dose- and duration-dependent manner. A linear relationship was observed between the concentration of PFOA and the activity of peroxisomal acyl-CoA oxidase in the liver of mice. These results strongly suggest that PFOA, but not 8-2 telomer alcohol itself, caused peroxisome proliferation in the liver. The present study provided evidence that 8-2 telomer alcohol is converted into PFOA in vivo and that the PFOA formed produces biological effects in the liver of mice." @default.
• W2010568711 created "2016-06-24" @default.
• W2010568711 creator A5004501644 @default.
• W2010568711 creator A5013756069 @default.
• W2010568711 creator A5044495128 @default.
• W2010568711 creator A5048243650 @default.
• W2010568711 creator A5061634903 @default.
• W2010568711 date "2005-05-11" @default.
• W2010568711 modified "2023-10-05" @default.
• W2010568711 title "Induction of Hepatic Peroxisome Proliferation by 8–2 Telomer Alcohol Feeding In Mice: Formation of Perfluorooctanoic Acid in the Liver" @default.
• W2010568711 cites W1775749144 @default.
• W2010568711 cites W1854337884 @default.
• W2010568711 cites W1966130148 @default.
• W2010568711 cites W1972258539 @default.
• W2010568711 cites W1980296829 @default.
• W2010568711 cites W1997309359 @default.
• W2010568711 cites W1998759224 @default.
• W2010568711 cites W2004024071 @default.
• W2010568711 cites W2005411425 @default.
• W2010568711 cites W2008202623 @default.
• W2010568711 cites W2021497766 @default.
• W2010568711 cites W2034901755 @default.
• W2010568711 cites W2035966708 @default.
• W2010568711 cites W2037232116 @default.
• W2010568711 cites W2040834378 @default.
• W2010568711 cites W2044990937 @default.
• W2010568711 cites W2049363299 @default.
• W2010568711 cites W2053849036 @default.
• W2010568711 cites W2054851279 @default.
• W2010568711 cites W2058154283 @default.
• W2010568711 cites W2064656679 @default.
• W2010568711 cites W2074058488 @default.
• W2010568711 cites W2081318196 @default.
• W2010568711 cites W2081345559 @default.
• W2010568711 cites W2094012249 @default.
• W2010568711 cites W2094210881 @default.
• W2010568711 cites W2125582966 @default.
• W2010568711 cites W2128172230 @default.
• W2010568711 cites W2200997159 @default.
• W2010568711 cites W45940357 @default.
• W2010568711 cites W5739282 @default.
• W2010568711 doi "https://doi.org/10.1093/toxsci/kfi191" @default.
• W2010568711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15888668" @default.
• W2010568711 hasPublicationYear "2005" @default.
• W2010568711 type Work @default.
• W2010568711 sameAs 2010568711 @default.
• W2010568711 citedByCount "67" @default.
• W2010568711 countsByYear W20105687112012 @default.
• W2010568711 countsByYear W20105687112013 @default.
• W2010568711 countsByYear W20105687112014 @default.
• W2010568711 countsByYear W20105687112015 @default.
• W2010568711 countsByYear W20105687112016 @default.
• W2010568711 countsByYear W20105687112017 @default.
• W2010568711 countsByYear W20105687112020 @default.
• W2010568711 countsByYear W20105687112021 @default.
• W2010568711 countsByYear W20105687112022 @default.
• W2010568711 crossrefType "journal-article" @default.
• W2010568711 hasAuthorship W2010568711A5004501644 @default.
• W2010568711 hasAuthorship W2010568711A5013756069 @default.
• W2010568711 hasAuthorship W2010568711A5044495128 @default.
• W2010568711 hasAuthorship W2010568711A5048243650 @default.
• W2010568711 hasAuthorship W2010568711A5061634903 @default.
• W2010568711 hasBestOaLocation W20105687111 @default.
• W2010568711 hasConcept C127078168 @default.
• W2010568711 hasConcept C170493617 @default.
• W2010568711 hasConcept C181199279 @default.
• W2010568711 hasConcept C185592680 @default.
• W2010568711 hasConcept C2775979320 @default.
• W2010568711 hasConcept C2777477808 @default.
• W2010568711 hasConcept C2781066024 @default.
• W2010568711 hasConcept C38485361 @default.
• W2010568711 hasConcept C55493867 @default.
• W2010568711 hasConceptScore W2010568711C127078168 @default.
• W2010568711 hasConceptScore W2010568711C170493617 @default.
• W2010568711 hasConceptScore W2010568711C181199279 @default.
• W2010568711 hasConceptScore W2010568711C185592680 @default.
• W2010568711 hasConceptScore W2010568711C2775979320 @default.
• W2010568711 hasConceptScore W2010568711C2777477808 @default.
• W2010568711 hasConceptScore W2010568711C2781066024 @default.
• W2010568711 hasConceptScore W2010568711C38485361 @default.
• W2010568711 hasConceptScore W2010568711C55493867 @default.
• W2010568711 hasIssue "2" @default.
• W2010568711 hasLocation W20105687111 @default.
• W2010568711 hasLocation W20105687112 @default.
• W2010568711 hasLocation W20105687113 @default.
• W2010568711 hasOpenAccess W2010568711 @default.
• W2010568711 hasPrimaryLocation W20105687111 @default.
• W2010568711 hasRelatedWork W1566601966 @default.
• W2010568711 hasRelatedWork W1686917753 @default.
• W2010568711 hasRelatedWork W2085566480 @default.
• W2010568711 hasRelatedWork W2092539446 @default.
• W2010568711 hasRelatedWork W2120637077 @default.
• W2010568711 hasRelatedWork W2402819143 @default.
• W2010568711 hasRelatedWork W2411855489 @default.
• W2010568711 hasRelatedWork W2425179490 @default.
• W2010568711 hasRelatedWork W4236507953 @default.
• W2010568711 hasRelatedWork W88401646 @default.
• W2010568711 hasVolume "86" @default.

• next