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- W2010574823 abstract "Abstract Either [3H]-progesterone ( 0.6 nmol 30 μCi ). or [14C]-progesterone ( 6.6 nmol 0.2 μCi ) plus [3H]-5α-pregnane-3,20-dione ( 0.5 nmol 0.5 μCi ), suspended in 5μl of physiological saline solution, was directly injected into the ovary at the central portion in 28- and 140-day-old rats. Following injection, radioactive metabolites in ovary and ovarian vein blood were extracted, isolated, measured and identified in the processes of column and paper chromatography, derivative formation, and finally recrystallization to constant specific activity. In the ovarian vein blood and ovaries of immature rats, major 17-OH-C21- and C19-metabolites of progesterone were 5α-reduced steroids such as 3α,17-dihydroxy-5α-pregnan-20-one, 3α-hydroxy-5α-androstan-17-one and 5α-androstane-3α,17β-diol. Following injection of [14C]-progesterone plus [3H]-5α-pregnane3,2O-dione into 28-day-old rat ovary, no significant augmentation of the isotope from progesterone was observed in 5α-reduced C19-steroids in the ovary as compared with 5α-reduced 17-OH-C21-steroids, as one compared the ratios of 3H/14C in 5α-reduced C19-steroids with that of 5α-reduced H-OH-C21-steroids, which were about the same. In the ovarian vein blood and ovaries of adult rats, only small amounts of 5α-reduced 17-oh-c21- and C19-metabolites derived from progesterone were found, while 20α-hydroxy-4-pregnen-3-one was the major metabolite. These findings suggest that the formation of 5α-reduced C19-steroids from progesterone by the 5α-reduced pathway is dominant in androgen biosynthesis of the immature rat ovary in vivo." @default.
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- W2010574823 title "Formation of 5α-reduced C19-steroids from progesterone in vivo by 5α-reduced pathway in immature rat ovaries" @default.
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- W2010574823 doi "https://doi.org/10.1016/0022-4731(78)90040-7" @default.
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