FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010577968> ?p ?o ?g. }

• W2010577968 endingPage "944" @default.
• W2010577968 startingPage "938" @default.
• W2010577968 abstract "Bisphosphonates suppress bone remodeling activity, increase bone volume, and significantly reduce fracture risk in individuals with osteoporosis and other metabolic bone diseases. The objectives of the current study were to develop a mathematical model that simulates control and 1 year experimental results following bisphosphonate treatment (alendronate or risedronate) in the canine fourth lumbar vertebral body, validate the model by comparing simulation predictions to 3 year experimental results, and then use the model to predict potential long term effects of bisphosphonates on remodeling and microdamage accumulation. To investigate the effects of bisphosphonates on bone volume and microdamage, a mechanistic biological model was modified from previous versions to simulate remodeling in a representative volume of vertebral trabecular bone in dogs treated with various doses of alendronate or risedronate, including doses equivalent to those used for treatment of post-menopausal osteoporosis in humans. Bisphosphonates were assumed to affect remodeling by suppressing basic multicellular unit activation and reducing resorption area. Model simulation results for trabecular bone volume fraction, microdamage, and activation frequency following 1 year of bisphosphonate treatment are consistent with experimental measurements. The model predicts that trabecular bone volume initially increases rapidly with 1 year of bisphosphonate treatment, and continues to slowly rise between 1 and 3 years of treatment. The model also predicts that microdamage initially increases rapidly, 0.5-1.5-fold for alendronate or risedronate during the first year of treatment, and reaches its maximum value by 2.5 years before trending downward for all dosages. The model developed in this study suggests that increasing bone volume fraction with long term bisphosphonate treatment may sufficiently reduce strain and damage formation rate so that microdamage does not accumulate above that which is initiated in the first two years of treatment." @default.
• W2010577968 created "2016-06-24" @default.
• W2010577968 creator A5021815774 @default.
• W2010577968 creator A5044936528 @default.
• W2010577968 creator A5056957230 @default.
• W2010577968 creator A5057370861 @default.
• W2010577968 creator A5063702959 @default.
• W2010577968 creator A5074102371 @default.
• W2010577968 date "2009-05-01" @default.
• W2010577968 modified "2023-10-09" @default.
• W2010577968 title "Theoretical analysis of alendronate and risedronate effects on canine vertebral remodeling and microdamage" @default.
• W2010577968 cites W1973448615 @default.
• W2010577968 cites W1974005588 @default.
• W2010577968 cites W1980718679 @default.
• W2010577968 cites W1989783674 @default.
• W2010577968 cites W1991618510 @default.
• W2010577968 cites W1992156727 @default.
• W2010577968 cites W1992837958 @default.
• W2010577968 cites W1993232754 @default.
• W2010577968 cites W2000466578 @default.
• W2010577968 cites W2003092614 @default.
• W2010577968 cites W2006398039 @default.
• W2010577968 cites W2008756438 @default.
• W2010577968 cites W2013783720 @default.
• W2010577968 cites W2014737217 @default.
• W2010577968 cites W2023781848 @default.
• W2010577968 cites W2030764448 @default.
• W2010577968 cites W2032354537 @default.
• W2010577968 cites W2032946274 @default.
• W2010577968 cites W2038294685 @default.
• W2010577968 cites W2039770739 @default.
• W2010577968 cites W2039930937 @default.
• W2010577968 cites W2040908824 @default.
• W2010577968 cites W2042353520 @default.
• W2010577968 cites W2048568696 @default.
• W2010577968 cites W2050003252 @default.
• W2010577968 cites W2050508925 @default.
• W2010577968 cites W2055031484 @default.
• W2010577968 cites W2057332307 @default.
• W2010577968 cites W2061472849 @default.
• W2010577968 cites W2064081312 @default.
• W2010577968 cites W2066663828 @default.
• W2010577968 cites W2071179794 @default.
• W2010577968 cites W2082239474 @default.
• W2010577968 cites W2091737798 @default.
• W2010577968 cites W2104922575 @default.
• W2010577968 cites W2123097481 @default.
• W2010577968 cites W2127210664 @default.
• W2010577968 cites W2137868736 @default.
• W2010577968 cites W2138907872 @default.
• W2010577968 cites W2139873752 @default.
• W2010577968 cites W2166307416 @default.
• W2010577968 cites W4256049814 @default.
• W2010577968 doi "https://doi.org/10.1016/j.jbiomech.2008.07.039" @default.
• W2010577968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2726830" @default.
• W2010577968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19285313" @default.
• W2010577968 hasPublicationYear "2009" @default.
• W2010577968 type Work @default.
• W2010577968 sameAs 2010577968 @default.
• W2010577968 citedByCount "10" @default.
• W2010577968 countsByYear W20105779682012 @default.
• W2010577968 countsByYear W20105779682013 @default.
• W2010577968 countsByYear W20105779682014 @default.
• W2010577968 countsByYear W20105779682016 @default.
• W2010577968 countsByYear W20105779682021 @default.
• W2010577968 countsByYear W20105779682022 @default.
• W2010577968 crossrefType "journal-article" @default.
• W2010577968 hasAuthorship W2010577968A5021815774 @default.
• W2010577968 hasAuthorship W2010577968A5044936528 @default.
• W2010577968 hasAuthorship W2010577968A5056957230 @default.
• W2010577968 hasAuthorship W2010577968A5057370861 @default.
• W2010577968 hasAuthorship W2010577968A5063702959 @default.
• W2010577968 hasAuthorship W2010577968A5074102371 @default.
• W2010577968 hasBestOaLocation W20105779682 @default.
• W2010577968 hasConcept C126322002 @default.
• W2010577968 hasConcept C126894567 @default.
• W2010577968 hasConcept C134018914 @default.
• W2010577968 hasConcept C146562846 @default.
• W2010577968 hasConcept C170033053 @default.
• W2010577968 hasConcept C2776541429 @default.
• W2010577968 hasConcept C2777251235 @default.
• W2010577968 hasConcept C2779329777 @default.
• W2010577968 hasConcept C2779809032 @default.
• W2010577968 hasConcept C2781104859 @default.
• W2010577968 hasConcept C2911223091 @default.
• W2010577968 hasConcept C673006 @default.
• W2010577968 hasConcept C71924100 @default.
• W2010577968 hasConceptScore W2010577968C126322002 @default.
• W2010577968 hasConceptScore W2010577968C126894567 @default.
• W2010577968 hasConceptScore W2010577968C134018914 @default.
• W2010577968 hasConceptScore W2010577968C146562846 @default.
• W2010577968 hasConceptScore W2010577968C170033053 @default.
• W2010577968 hasConceptScore W2010577968C2776541429 @default.
• W2010577968 hasConceptScore W2010577968C2777251235 @default.
• W2010577968 hasConceptScore W2010577968C2779329777 @default.
• W2010577968 hasConceptScore W2010577968C2779809032 @default.
• W2010577968 hasConceptScore W2010577968C2781104859 @default.
• W2010577968 hasConceptScore W2010577968C2911223091 @default.

• next