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• W2010582036 abstract "Oral contraceptive steroids may undergo enterohepatic circulation, but it is relevant for only estrogens, because these compounds can be directly conjugated in the liver. Animal studies show convincing evidence of the importance of the enterohepatic circulation, but studies in humans are much less convincing. The importance of the route and the rate of metabolism of ethinyl estradiol are reviewed. Some antibiotics have been reported anecdotally to reduce the efficacy of oral contraceptive steroids, but controlled stuides have not confirmed this observation. Although gut flora are altered by oral antibotics, the blood levels of ethinyl estradiol are not reduced, and one antibiotic at least (cotrimoxazole) enhances the activity of ethinyl estradiol." @default.
• W2010582036 created "2016-06-24" @default.
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• W2010582036 creator A5046120879 @default.
• W2010582036 date "1990-12-01" @default.
• W2010582036 modified "2023-10-17" @default.
• W2010582036 title "Factors affecting the enterohepatic circulation of oral contraceptive steroids" @default.
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• W2010582036 doi "https://doi.org/10.1016/0002-9378(90)90555-l" @default.
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