FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010586937> ?p ?o ?g. }

• W2010586937 endingPage "15823" @default.
• W2010586937 startingPage "15815" @default.
• W2010586937 abstract "The nitrosation of cellular thiols has attracted much interest as a regulatory mechanism that mediates some of the pathophysiological effects of nitric oxide (NO). In cells, virtually all enzymes contain cysteine residues that can be subjected to S-nitrosation, whereby this process often acts as an activity switch. Nitrosation of biological thiols is believed to be mediated by N2O3, metal-nitrosyl complexes, and peroxynitrite. To date, however, enzymatic pathways for S-denitrosation of proteins have not been identified. Herein, we present experimental evidence that two ubiquitous cellular dithiols, thioredoxin and dihydrolipoic acid, catalyze the denitrosation of S-nitrosoglutathione, S-nitrosocaspase 3, S-nitrosoalbumin, and S-nitrosometallothionenin to their reduced state with concomitant generation of nitroxyl (HNO), the one-electron reduction product of NO. In these reactions, formation of NO and HNO was assessed by ESR spectrometry, potentiometric measurements, and quantification of hydroxylamine and sodium nitrite as end reaction products. Nitrosation and denitrosation of caspase 3 was correlated with its proteolytic activity. We also report that thioredoxin-deficient HeLa cells with mutated thioredoxin reductase denitrosate S-nitrosothiols less efficiently. We conclude that both thioredoxin and dihydrolipoic acid may be involved in the regulation of cellular S-nitrosothiols." @default.
• W2010586937 created "2016-06-24" @default.
• W2010586937 creator A5021339980 @default.
• W2010586937 creator A5025786667 @default.
• W2010586937 creator A5032930499 @default.
• W2010586937 creator A5040760802 @default.
• W2010586937 creator A5055133721 @default.
• W2010586937 creator A5062076820 @default.
• W2010586937 creator A5066826029 @default.
• W2010586937 creator A5073767193 @default.
• W2010586937 creator A5086611091 @default.
• W2010586937 creator A5089626875 @default.
• W2010586937 date "2005-10-20" @default.
• W2010586937 modified "2023-10-14" @default.
• W2010586937 title "Thioredoxin and Lipoic Acid Catalyze the Denitrosation of Low Molecular Weight and Protein<i>S</i>-Nitrosothiols" @default.
• W2010586937 cites W1023736352 @default.
• W2010586937 cites W1488493608 @default.
• W2010586937 cites W1551392207 @default.
• W2010586937 cites W1564875712 @default.
• W2010586937 cites W1570089337 @default.
• W2010586937 cites W1579166524 @default.
• W2010586937 cites W1595838029 @default.
• W2010586937 cites W1613263812 @default.
• W2010586937 cites W1823861229 @default.
• W2010586937 cites W1844185706 @default.
• W2010586937 cites W1964058023 @default.
• W2010586937 cites W1976257781 @default.
• W2010586937 cites W1976645176 @default.
• W2010586937 cites W1977448081 @default.
• W2010586937 cites W1981561121 @default.
• W2010586937 cites W1982456140 @default.
• W2010586937 cites W1992281852 @default.
• W2010586937 cites W1993058298 @default.
• W2010586937 cites W2005205544 @default.
• W2010586937 cites W2006105383 @default.
• W2010586937 cites W2006172842 @default.
• W2010586937 cites W2010055809 @default.
• W2010586937 cites W2013132802 @default.
• W2010586937 cites W2015752494 @default.
• W2010586937 cites W2021222257 @default.
• W2010586937 cites W2023882972 @default.
• W2010586937 cites W2024559949 @default.
• W2010586937 cites W2024921655 @default.
• W2010586937 cites W2026760680 @default.
• W2010586937 cites W2034334015 @default.
• W2010586937 cites W2034937253 @default.
• W2010586937 cites W2034946903 @default.
• W2010586937 cites W2040049703 @default.
• W2010586937 cites W2045429393 @default.
• W2010586937 cites W2047609920 @default.
• W2010586937 cites W2049236874 @default.
• W2010586937 cites W2049861842 @default.
• W2010586937 cites W2050264954 @default.
• W2010586937 cites W2054027791 @default.
• W2010586937 cites W2063078080 @default.
• W2010586937 cites W2065020384 @default.
• W2010586937 cites W2067290020 @default.
• W2010586937 cites W2070263356 @default.
• W2010586937 cites W2071348092 @default.
• W2010586937 cites W2071468228 @default.
• W2010586937 cites W2077792640 @default.
• W2010586937 cites W2077881877 @default.
• W2010586937 cites W2081376324 @default.
• W2010586937 cites W2084738458 @default.
• W2010586937 cites W2089047541 @default.
• W2010586937 cites W2089291135 @default.
• W2010586937 cites W2090147611 @default.
• W2010586937 cites W2090280224 @default.
• W2010586937 cites W2094801957 @default.
• W2010586937 cites W2103230358 @default.
• W2010586937 cites W2114379838 @default.
• W2010586937 cites W2114939565 @default.
• W2010586937 cites W2115336136 @default.
• W2010586937 cites W2129415401 @default.
• W2010586937 cites W2132863919 @default.
• W2010586937 cites W2137598362 @default.
• W2010586937 cites W2144157272 @default.
• W2010586937 cites W2149429100 @default.
• W2010586937 cites W2156597317 @default.
• W2010586937 cites W2161600441 @default.
• W2010586937 cites W2314801013 @default.
• W2010586937 cites W2951701975 @default.
• W2010586937 cites W2951820609 @default.
• W2010586937 cites W3025746616 @default.
• W2010586937 cites W4240754801 @default.
• W2010586937 cites W4247896860 @default.
• W2010586937 doi "https://doi.org/10.1021/ja0529135" @default.
• W2010586937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16277524" @default.
• W2010586937 hasPublicationYear "2005" @default.
• W2010586937 type Work @default.
• W2010586937 sameAs 2010586937 @default.
• W2010586937 citedByCount "162" @default.
• W2010586937 countsByYear W20105869372012 @default.
• W2010586937 countsByYear W20105869372013 @default.
• W2010586937 countsByYear W20105869372014 @default.
• W2010586937 countsByYear W20105869372015 @default.
• W2010586937 countsByYear W20105869372016 @default.
• W2010586937 countsByYear W20105869372017 @default.

• next