FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010587277> ?p ?o ?g. }

• W2010587277 endingPage "816" @default.
• W2010587277 startingPage "809" @default.
• W2010587277 abstract "Functional magnetic resonance imaging (fMRI) provides an indirect reflection of neural activity change in the working brain through detection of blood oxygenation level dependent (BOLD) signal changes. Although widely used to map patterns of brain activation, fMRI has not yet met its potential for clinical and pharmacological studies due to difficulties in quantitatively interpreting the BOLD signal. This difficulty is due to the BOLD response being strongly modulated by two physiological factors in addition to the level of neural activity: the amount of deoxyhemoglobin present in the baseline state and the coupling ratio, n, of evoked changes in blood flow and oxygen metabolism. In this study, we used a quantitative fMRI approach with dual measurement of blood flow and BOLD responses to overcome these limitations and show that these two sources of modulation work in opposite directions following caffeine administration in healthy human subjects. A strong 27% reduction in baseline blood flow and a 22% increase in baseline oxygen metabolism after caffeine consumption led to a decrease in baseline blood oxygenation and were expected to increase the subsequent BOLD response to the visual stimulus. Opposing this, caffeine reduced n through a strong 61% increase in the evoked oxygen metabolism response to the visual stimulus. The combined effect was that BOLD responses pre- and post-caffeine were similar despite large underlying physiological changes, indicating that the magnitude of the BOLD response alone should not be interpreted as a direct measure of underlying neurophysiological changes. Instead, a quantitative methodology based on dual-echo measurement of blood flow and BOLD responses is a promising tool for applying fMRI to disease and drug studies in which both baseline conditions and the coupling of blood flow and oxygen metabolism responses to a stimulus may be altered." @default.
• W2010587277 created "2016-06-24" @default.
• W2010587277 creator A5008134867 @default.
• W2010587277 creator A5028012659 @default.
• W2010587277 creator A5079442137 @default.
• W2010587277 date "2011-08-01" @default.
• W2010587277 modified "2023-09-30" @default.
• W2010587277 title "Prospects for quantitative fMRI: Investigating the effects of caffeine on baseline oxygen metabolism and the response to a visual stimulus in humans" @default.
• W2010587277 cites W1599336280 @default.
• W2010587277 cites W1648853544 @default.
• W2010587277 cites W1965289522 @default.
• W2010587277 cites W1965315090 @default.
• W2010587277 cites W1971761295 @default.
• W2010587277 cites W1981813007 @default.
• W2010587277 cites W1994192509 @default.
• W2010587277 cites W1996964516 @default.
• W2010587277 cites W2001467170 @default.
• W2010587277 cites W2003256029 @default.
• W2010587277 cites W2006763251 @default.
• W2010587277 cites W2012056804 @default.
• W2010587277 cites W2015511270 @default.
• W2010587277 cites W2016306388 @default.
• W2010587277 cites W2019526570 @default.
• W2010587277 cites W2020633711 @default.
• W2010587277 cites W2025613729 @default.
• W2010587277 cites W2036537915 @default.
• W2010587277 cites W2042422091 @default.
• W2010587277 cites W2047237446 @default.
• W2010587277 cites W2054872162 @default.
• W2010587277 cites W2055111173 @default.
• W2010587277 cites W2056050988 @default.
• W2010587277 cites W2057280125 @default.
• W2010587277 cites W2060319077 @default.
• W2010587277 cites W2064818171 @default.
• W2010587277 cites W2068914689 @default.
• W2010587277 cites W2069076769 @default.
• W2010587277 cites W2073916850 @default.
• W2010587277 cites W2075556735 @default.
• W2010587277 cites W2076420959 @default.
• W2010587277 cites W2081615090 @default.
• W2010587277 cites W2088774650 @default.
• W2010587277 cites W2091910719 @default.
• W2010587277 cites W2092930162 @default.
• W2010587277 cites W2094357416 @default.
• W2010587277 cites W2113389052 @default.
• W2010587277 cites W2116721966 @default.
• W2010587277 cites W2120800380 @default.
• W2010587277 cites W2123526233 @default.
• W2010587277 cites W2125972553 @default.
• W2010587277 cites W2133710105 @default.
• W2010587277 cites W2133875665 @default.
• W2010587277 cites W2140124534 @default.
• W2010587277 cites W2145758516 @default.
• W2010587277 cites W2146903472 @default.
• W2010587277 cites W2147778078 @default.
• W2010587277 cites W2148992333 @default.
• W2010587277 cites W2150177485 @default.
• W2010587277 cites W2152346792 @default.
• W2010587277 cites W2160560122 @default.
• W2010587277 cites W2166486417 @default.
• W2010587277 doi "https://doi.org/10.1016/j.neuroimage.2011.04.064" @default.
• W2010587277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172084" @default.
• W2010587277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21586328" @default.
• W2010587277 hasPublicationYear "2011" @default.
• W2010587277 type Work @default.
• W2010587277 sameAs 2010587277 @default.
• W2010587277 citedByCount "73" @default.
• W2010587277 countsByYear W20105872772012 @default.
• W2010587277 countsByYear W20105872772013 @default.
• W2010587277 countsByYear W20105872772014 @default.
• W2010587277 countsByYear W20105872772015 @default.
• W2010587277 countsByYear W20105872772016 @default.
• W2010587277 countsByYear W20105872772017 @default.
• W2010587277 countsByYear W20105872772018 @default.
• W2010587277 countsByYear W20105872772019 @default.
• W2010587277 countsByYear W20105872772020 @default.
• W2010587277 countsByYear W20105872772021 @default.
• W2010587277 countsByYear W20105872772022 @default.
• W2010587277 countsByYear W20105872772023 @default.
• W2010587277 crossrefType "journal-article" @default.
• W2010587277 hasAuthorship W2010587277A5008134867 @default.
• W2010587277 hasAuthorship W2010587277A5028012659 @default.
• W2010587277 hasAuthorship W2010587277A5079442137 @default.
• W2010587277 hasBestOaLocation W20105872772 @default.
• W2010587277 hasConcept C120843803 @default.
• W2010587277 hasConcept C126322002 @default.
• W2010587277 hasConcept C15744967 @default.
• W2010587277 hasConcept C157767197 @default.
• W2010587277 hasConcept C158846371 @default.
• W2010587277 hasConcept C169760540 @default.
• W2010587277 hasConcept C180747234 @default.
• W2010587277 hasConcept C26170363 @default.
• W2010587277 hasConcept C2777953023 @default.
• W2010587277 hasConcept C2778500429 @default.
• W2010587277 hasConcept C2779226451 @default.
• W2010587277 hasConcept C2779345533 @default.
• W2010587277 hasConcept C2779918689 @default.
• W2010587277 hasConcept C2780238834 @default.

• next