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• W2010592389 abstract "We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain-derived neurotrophic factor and neurotrophin-4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects." @default.
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• W2010592389 date "2008-04-18" @default.
• W2010592389 modified "2023-10-16" @default.
• W2010592389 title "A Model for Neuronal Competition During Development" @default.
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• W2010592389 doi "https://doi.org/10.1126/science.1152677" @default.
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