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• W2010597170 startingPage "9697" @default.
• W2010597170 abstract "DNA is subject to constant oxidative damage from endogenous oxidants. The oxidized DNA is continuously repaired and the oxidized bases are excreted in the urine. A simple routine analytical procedure is described for urinary 8-hydroxy-2'-deoxyguanosine, an oxidative DNA damage adduct, as an indicator of oxidative damage in humans and rodents. This adduct was purified from human urine and characterized. The described assay employs a series of solid-phase extraction steps that separate 8-hydroxy-2'-deoxyguanosine from other urinary constituents, followed by analysis by gradient reversed-phase HPLC coupled to a dual-electrode high-efficiency electrochemical detection system. Analysis of urine from three species by this method indicates that mice excrete approximately 3.3-fold more 8-hydroxy-2'-deoxyguanosine than humans (582 vs. 178 residues per cell per day), a result that supports the proposal that oxidative damage to DNA increases in proportion to species-specific basal metabolic rates." @default.
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• W2010597170 date "1989-12-01" @default.
• W2010597170 modified "2023-10-09" @default.
• W2010597170 title "Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage." @default.
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• W2010597170 doi "https://doi.org/10.1073/pnas.86.24.9697" @default.
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