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- W2010599783 abstract "Acute stroke is one of the major causes of death and disabilities. Since the 1980s many clinical studies have been conducted to evaluate neuroprotective approaches to treat this important brain vascular event. However, to date the only drug approved (recombinant tissue plasminogen activator [rtPA]) represents a thrombolytic, nonneuroprotective approach. An important neuroprotective strategy is based on erythropoietin (EPO). Exogenously administered EPO exhibits neuroprotective effects in numerous animal models, through the activation of anti-apoptotic, anti-oxidant and anti-inflammatory pathways as well as through the stimulation of angiogenic and neurogenic events. The capability of EPO to cross the blood-brain barrier after systemic administration and its effective therapeutic window are advantages for human acute stroke therapy. However, a multicenter stroke trial where recombinant human EPO (rhEPO) was combined with rtPA had negative outcomes. The present paper reviews the EPO neuroprotective strategy and its mechanisms in ischemic stroke and in other human nervous system diseases." @default.
- W2010599783 created "2016-06-24" @default.
- W2010599783 creator A5017125637 @default.
- W2010599783 creator A5038700899 @default.
- W2010599783 creator A5054987194 @default.
- W2010599783 date "2012-03-20" @default.
- W2010599783 modified "2023-09-26" @default.
- W2010599783 title "Erythropoietin: still on the neuroprotection road" @default.
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- W2010599783 doi "https://doi.org/10.1177/1756285611434926" @default.
- W2010599783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3349080" @default.
- W2010599783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22590480" @default.