FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010603227> ?p ?o ?g. }

• W2010603227 endingPage "7" @default.
• W2010603227 startingPage "1" @default.
• W2010603227 abstract "Type 2 diabetes is a prototypical complex systems disease that has a strong hereditary component and etiologic links with a sedentary lifestyle, overeating and obesity. Adipose tissue has been shown to be a central driver of type 2 diabetes progression, establishing and maintaining a chronic state of low-level inflammation. The number and diversity of identified endocrine factors from adipose tissue (adipokines) is growing rapidly. Here, I argue that a systems biology approach to understanding the robust multi-level signaling networks established by the adipose secretome will be crucial for developing efficient type 2 diabetes treatment. Recent advances in whole-genome association studies, global molecular profiling and quantitative modeling are currently fueling the emergence of this novel research strategy. Type 2 diabetes is a prototypical complex systems disease that has a strong hereditary component and etiologic links with a sedentary lifestyle, overeating and obesity. Adipose tissue has been shown to be a central driver of type 2 diabetes progression, establishing and maintaining a chronic state of low-level inflammation. The number and diversity of identified endocrine factors from adipose tissue (adipokines) is growing rapidly. Here, I argue that a systems biology approach to understanding the robust multi-level signaling networks established by the adipose secretome will be crucial for developing efficient type 2 diabetes treatment. Recent advances in whole-genome association studies, global molecular profiling and quantitative modeling are currently fueling the emergence of this novel research strategy. also known as adipocytokines. Cell-to-cell signaling proteins and peptides secreted by various cells in the adipose tissue, including adipocytes and tissue macrophages. Adipokines act locally or systemically by modulating the function of the immune system. More than a dozen major adipokines are currently known. the entirety of signaling molecules secreted by adipose tissue including hormones, adipokines and lipids. the absence of an adequate response to normal levels of insulin, which often precedes the development of diabetes. quantitative information about molecular concentrations and reaction kinetics, which is required for detailed predictive modeling of signaling pathways. peroxisome proliferator-activated receptor γ. Nuclear receptor with major effects on adipocyte differentiation. PPARγ is the main target of antidiabetic drugs of the thiazolidinedione type. the ability of a biological system to function in a variety of environmental conditions. In advanced diabetes, the diseased system exhibits robust properties that make it unresponsive to medical intervention. computational models of biological systems that combine qualitative (topological) descriptions of molecule–molecule interactions and quantitative descriptions of individual reactions. Such models can be particularly useful in the absence of comprehensive parameter information. tumor necrosis factor α. Cytokine involved in chronic inflammation. Secretion of large amounts of TNFα as an adipokine is supposed to have a major role in the maintenance of a chronic inflamed state in diabetes." @default.
• W2010603227 created "2016-06-24" @default.
• W2010603227 creator A5070145336 @default.
• W2010603227 date "2009-01-01" @default.
• W2010603227 modified "2023-10-18" @default.
• W2010603227 title "Robust signaling networks of the adipose secretome" @default.
• W2010603227 cites W1548248963 @default.
• W2010603227 cites W1554123323 @default.
• W2010603227 cites W1744632804 @default.
• W2010603227 cites W1854820983 @default.
• W2010603227 cites W1857817679 @default.
• W2010603227 cites W1964478846 @default.
• W2010603227 cites W1964991966 @default.
• W2010603227 cites W1965141016 @default.
• W2010603227 cites W1967206579 @default.
• W2010603227 cites W1974135424 @default.
• W2010603227 cites W1975783279 @default.
• W2010603227 cites W1979833590 @default.
• W2010603227 cites W1986397618 @default.
• W2010603227 cites W1988141914 @default.
• W2010603227 cites W2000054651 @default.
• W2010603227 cites W2001727439 @default.
• W2010603227 cites W2004616994 @default.
• W2010603227 cites W2004969093 @default.
• W2010603227 cites W2009412756 @default.
• W2010603227 cites W2012705303 @default.
• W2010603227 cites W2021650676 @default.
• W2010603227 cites W2023178691 @default.
• W2010603227 cites W2031882974 @default.
• W2010603227 cites W2036519287 @default.
• W2010603227 cites W2039934598 @default.
• W2010603227 cites W2040643166 @default.
• W2010603227 cites W2042880070 @default.
• W2010603227 cites W2051051060 @default.
• W2010603227 cites W2058227073 @default.
• W2010603227 cites W2059511498 @default.
• W2010603227 cites W2068188831 @default.
• W2010603227 cites W2083869247 @default.
• W2010603227 cites W2090808827 @default.
• W2010603227 cites W2091901410 @default.
• W2010603227 cites W2092422666 @default.
• W2010603227 cites W2100525485 @default.
• W2010603227 cites W2110658722 @default.
• W2010603227 cites W2110743053 @default.
• W2010603227 cites W2114041992 @default.
• W2010603227 cites W2116054884 @default.
• W2010603227 cites W2119519672 @default.
• W2010603227 cites W2120480222 @default.
• W2010603227 cites W2126490636 @default.
• W2010603227 cites W2129316761 @default.
• W2010603227 cites W2129618124 @default.
• W2010603227 cites W2131368577 @default.
• W2010603227 cites W2131636689 @default.
• W2010603227 cites W2135110328 @default.
• W2010603227 cites W2138842915 @default.
• W2010603227 cites W2143784594 @default.
• W2010603227 cites W2151025367 @default.
• W2010603227 cites W2156353972 @default.
• W2010603227 cites W2158288207 @default.
• W2010603227 cites W2164542975 @default.
• W2010603227 cites W2171835251 @default.
• W2010603227 cites W2174569309 @default.
• W2010603227 cites W4232283021 @default.
• W2010603227 doi "https://doi.org/10.1016/j.tem.2008.08.006" @default.
• W2010603227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18930409" @default.
• W2010603227 hasPublicationYear "2009" @default.
• W2010603227 type Work @default.
• W2010603227 sameAs 2010603227 @default.
• W2010603227 citedByCount "24" @default.
• W2010603227 countsByYear W20106032272012 @default.
• W2010603227 countsByYear W20106032272013 @default.
• W2010603227 countsByYear W20106032272014 @default.
• W2010603227 countsByYear W20106032272015 @default.
• W2010603227 countsByYear W20106032272016 @default.
• W2010603227 countsByYear W20106032272018 @default.
• W2010603227 crossrefType "journal-article" @default.
• W2010603227 hasAuthorship W2010603227A5070145336 @default.
• W2010603227 hasBestOaLocation W20106032272 @default.
• W2010603227 hasConcept C126322002 @default.
• W2010603227 hasConcept C134018914 @default.
• W2010603227 hasConcept C171089720 @default.
• W2010603227 hasConcept C194832188 @default.
• W2010603227 hasConcept C203014093 @default.
• W2010603227 hasConcept C2776914184 @default.
• W2010603227 hasConcept C2777180221 @default.
• W2010603227 hasConcept C2777391703 @default.
• W2010603227 hasConcept C2779134260 @default.
• W2010603227 hasConcept C511355011 @default.
• W2010603227 hasConcept C555293320 @default.
• W2010603227 hasConcept C60644358 @default.
• W2010603227 hasConcept C70721500 @default.
• W2010603227 hasConcept C71924100 @default.
• W2010603227 hasConcept C86803240 @default.
• W2010603227 hasConceptScore W2010603227C126322002 @default.
• W2010603227 hasConceptScore W2010603227C134018914 @default.
• W2010603227 hasConceptScore W2010603227C171089720 @default.
• W2010603227 hasConceptScore W2010603227C194832188 @default.
• W2010603227 hasConceptScore W2010603227C203014093 @default.

• next