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• W2010605216 abstract "In order to maintain tissue homeostasis, cell fate decisions within stem cell lineages have to respond to the needs of the tissue. This coordination of lineage choices with regenerative demand remains poorly characterized. Here, we identify a signal from enteroendocrine cells (EEs) that controls lineage specification in the Drosophila intestine. We find that EEs secrete Slit, a ligand for the Robo2 receptor in intestinal stem cells (ISCs) that limits ISC commitment to the endocrine lineage, establishing negative feedback control of EE regeneration. Furthermore, we show that this lineage decision is made within ISCs and requires induction of the transcription factor Prospero in ISCs. Our work identifies a function for the conserved Slit/Robo pathway in the regulation of adult stem cells, establishing negative feedback control of ISC lineage specification as a critical strategy to preserve tissue homeostasis. Our results further amend the current understanding of cell fate commitment within the Drosophila ISC lineage." @default.
• W2010605216 created "2016-06-24" @default.
• W2010605216 creator A5063179526 @default.
• W2010605216 creator A5074287735 @default.
• W2010605216 date "2014-06-01" @default.
• W2010605216 modified "2023-10-14" @default.
• W2010605216 title "Slit/Robo Signaling Regulates Cell Fate Decisions in the Intestinal Stem Cell Lineage of Drosophila" @default.
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• W2010605216 doi "https://doi.org/10.1016/j.celrep.2014.05.024" @default.
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