FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010605429> ?p ?o ?g. }

• W2010605429 abstract "Our ever-increasing knowledge of the human genome has revealed the genetic basis underlying many diseases while simultaneously providing us with a greater understanding of normal intraspecies genetic variability. This raises the possibility that as twenty-first century physicians, we will be able to practice a personalized form of medicine specifically tailored to the genetic makeup of each patient. One key question for anesthesiology is how clinically relevant is genetic diversity in the day-to-day practice of anesthesia. In the present issue of the journal, Alone and colleagues studied the effect of genomic copy number variation (CNV) on volatile anesthetic sensitivity. 1 Recent work has demonstrated that CNV is one of the most important determinants of genetic variability in humans. 2 CNV is a type of polymorphism defined as a segment of DNA, measuring several thousand to several million base pairs, whose number of copies encoded in the genome differ among two or more individuals of the same species. 3 Chromosomal duplications, deletions, rearrangements, and insertions all give rise to CNV. It is thought that predisposition to a growing number of complex diseases might be explained by CNV, including some forms of neuropsychiatric illnesses, malaria, and human immunodeficiency virus susceptibility. 4 Despite the overall small phenotypic variability in a population's volatile anesthetic responsiveness, reflected by the familiar steep slopes intrinsic to anesthetic dose-response curves, phenotypic variation to anesthetics does exist. This variation arises both from environmental and genetic factors. 5 It is conceivable that CNV might contribute to the diversity in anesthetic responsiveness including rare phenotypes such as partial resistance or hypersensitivity. Among the many interesting ways such extreme phenotypes could manifest are awareness under anesthesia or delayed emergence. From a practical standpoint, however, genotyping CNV and determining the allelic state of any given individual in human studies remains technically challenging. Therefore, to study the impact of CNV on anesthetic sensitivity, Alone and collaborators have made use of the many advantages available for the Drosophila model system. 1 The fruit fly, Drosophila melanogaster, might at first seem like an unusual choice organism to study a human problem. Most are more familiar with modeling human conditions in mammals. Several tantalizing genetic sites are already known to affect sensitivity in rodents. Mice bred for differential sensitivity to alcohol also display differential sensitivity to a variety" @default.
• W2010605429 created "2016-06-24" @default.
• W2010605429 creator A5007293568 @default.
• W2010605429 creator A5078031867 @default.
• W2010605429 date "2009-07-01" @default.
• W2010605429 modified "2023-09-26" @default.
• W2010605429 title "Anesthetic Sensitivity" @default.
• W2010605429 cites W1966938977 @default.
• W2010605429 cites W1967632947 @default.
• W2010605429 cites W1974398081 @default.
• W2010605429 cites W1976962038 @default.
• W2010605429 cites W2017523407 @default.
• W2010605429 cites W2022368965 @default.
• W2010605429 cites W2022929911 @default.
• W2010605429 cites W2036537186 @default.
• W2010605429 cites W2056213320 @default.
• W2010605429 cites W2068400797 @default.
• W2010605429 cites W2068759007 @default.
• W2010605429 cites W2074579392 @default.
• W2010605429 cites W2081923378 @default.
• W2010605429 cites W2119706891 @default.
• W2010605429 cites W2130748980 @default.
• W2010605429 cites W2154414197 @default.
• W2010605429 cites W2155707112 @default.
• W2010605429 doi "https://doi.org/10.1097/aln.0b013e3181a3278b" @default.
• W2010605429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2728351" @default.
• W2010605429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19512880" @default.
• W2010605429 hasPublicationYear "2009" @default.
• W2010605429 type Work @default.
• W2010605429 sameAs 2010605429 @default.
• W2010605429 citedByCount "1" @default.
• W2010605429 countsByYear W20106054292020 @default.
• W2010605429 crossrefType "journal-article" @default.
• W2010605429 hasAuthorship W2010605429A5007293568 @default.
• W2010605429 hasAuthorship W2010605429A5078031867 @default.
• W2010605429 hasBestOaLocation W20106054291 @default.
• W2010605429 hasConcept C104317684 @default.
• W2010605429 hasConcept C106208931 @default.
• W2010605429 hasConcept C120821319 @default.
• W2010605429 hasConcept C135763542 @default.
• W2010605429 hasConcept C141231307 @default.
• W2010605429 hasConcept C142724271 @default.
• W2010605429 hasConcept C153209595 @default.
• W2010605429 hasConcept C197077220 @default.
• W2010605429 hasConcept C2778162923 @default.
• W2010605429 hasConcept C2779134260 @default.
• W2010605429 hasConcept C2779526319 @default.
• W2010605429 hasConcept C2908647359 @default.
• W2010605429 hasConcept C2991975920 @default.
• W2010605429 hasConcept C42219234 @default.
• W2010605429 hasConcept C54355233 @default.
• W2010605429 hasConcept C68873052 @default.
• W2010605429 hasConcept C71924100 @default.
• W2010605429 hasConcept C78458016 @default.
• W2010605429 hasConcept C81977670 @default.
• W2010605429 hasConcept C86803240 @default.
• W2010605429 hasConcept C99454951 @default.
• W2010605429 hasConceptScore W2010605429C104317684 @default.
• W2010605429 hasConceptScore W2010605429C106208931 @default.
• W2010605429 hasConceptScore W2010605429C120821319 @default.
• W2010605429 hasConceptScore W2010605429C135763542 @default.
• W2010605429 hasConceptScore W2010605429C141231307 @default.
• W2010605429 hasConceptScore W2010605429C142724271 @default.
• W2010605429 hasConceptScore W2010605429C153209595 @default.
• W2010605429 hasConceptScore W2010605429C197077220 @default.
• W2010605429 hasConceptScore W2010605429C2778162923 @default.
• W2010605429 hasConceptScore W2010605429C2779134260 @default.
• W2010605429 hasConceptScore W2010605429C2779526319 @default.
• W2010605429 hasConceptScore W2010605429C2908647359 @default.
• W2010605429 hasConceptScore W2010605429C2991975920 @default.
• W2010605429 hasConceptScore W2010605429C42219234 @default.
• W2010605429 hasConceptScore W2010605429C54355233 @default.
• W2010605429 hasConceptScore W2010605429C68873052 @default.
• W2010605429 hasConceptScore W2010605429C71924100 @default.
• W2010605429 hasConceptScore W2010605429C78458016 @default.
• W2010605429 hasConceptScore W2010605429C81977670 @default.
• W2010605429 hasConceptScore W2010605429C86803240 @default.
• W2010605429 hasConceptScore W2010605429C99454951 @default.
• W2010605429 hasLocation W20106054291 @default.
• W2010605429 hasLocation W20106054292 @default.
• W2010605429 hasLocation W20106054293 @default.
• W2010605429 hasOpenAccess W2010605429 @default.
• W2010605429 hasPrimaryLocation W20106054291 @default.
• W2010605429 hasRelatedWork W1556971805 @default.
• W2010605429 hasRelatedWork W1970562090 @default.
• W2010605429 hasRelatedWork W1975322179 @default.
• W2010605429 hasRelatedWork W1999440987 @default.
• W2010605429 hasRelatedWork W2036299371 @default.
• W2010605429 hasRelatedWork W2053767652 @default.
• W2010605429 hasRelatedWork W2053801919 @default.
• W2010605429 hasRelatedWork W2085235236 @default.
• W2010605429 hasRelatedWork W2094295010 @default.
• W2010605429 hasRelatedWork W2119315877 @default.
• W2010605429 hasRelatedWork W2159907330 @default.
• W2010605429 hasRelatedWork W2168713159 @default.
• W2010605429 hasRelatedWork W2189416883 @default.
• W2010605429 hasRelatedWork W2336487940 @default.
• W2010605429 hasRelatedWork W2381167975 @default.
• W2010605429 hasRelatedWork W2586231603 @default.
• W2010605429 hasRelatedWork W2606988772 @default.

• next