FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010607835> ?p ?o ?g. }

• W2010607835 endingPage "53" @default.
• W2010607835 startingPage "44" @default.
• W2010607835 abstract "There is increasing evidence that epithelial-vascular interactions are essential for tissue patterning. Here we identified components of the molecular cross talk between respiratory epithelial cells and pulmonary capillaries necessary for the formation of the gas exchange surface of the lung. Selective inactivation of the Vegf-A gene in respiratory epithelium results in an almost complete absence of pulmonary capillaries, demonstrating the dependence of pulmonary capillary development on epithelium-derived Vegf-A. Deficient capillary formation in Vegf-A deficient lungs is associated with a defect in primary septae formation, a morphogenetic process critical for distal lung morphogenesis, coupled with suppression of epithelial cell proliferation and decreased hepatocyte growth factor (Hgf) expression. Lung endothelial cells express Hgf, and selective deletion of the Hgf receptor gene in respiratory epithelium phenocopies the malformation of septae, confirming the requirement for epithelial Hgf signaling in normal septae formation and suggesting that Hgf serves as an endothelium-derived factor that signals to the epithelium. Our findings support a mechanism for primary septae formation dependent on reciprocal interactions between respiratory epithelium and the underlying vasculature, establishing the dependence of pulmonary capillary development on epithelium-derived Vegf-A, and identify Hgf as a putative endothelium-derived factor that mediates the reciprocal signaling from the vasculature to the respiratory epithelium." @default.
• W2010607835 created "2016-06-24" @default.
• W2010607835 creator A5001813162 @default.
• W2010607835 creator A5036256585 @default.
• W2010607835 creator A5036881362 @default.
• W2010607835 creator A5037270460 @default.
• W2010607835 creator A5052067361 @default.
• W2010607835 creator A5056084313 @default.
• W2010607835 date "2007-08-01" @default.
• W2010607835 modified "2023-10-03" @default.
• W2010607835 title "Epithelial–vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis" @default.
• W2010607835 cites W1498587827 @default.
• W2010607835 cites W1607596367 @default.
• W2010607835 cites W1967291020 @default.
• W2010607835 cites W1969449517 @default.
• W2010607835 cites W1978514461 @default.
• W2010607835 cites W1980247655 @default.
• W2010607835 cites W1984808967 @default.
• W2010607835 cites W1987306181 @default.
• W2010607835 cites W1993744211 @default.
• W2010607835 cites W1995595526 @default.
• W2010607835 cites W1998479997 @default.
• W2010607835 cites W2003598961 @default.
• W2010607835 cites W2007413389 @default.
• W2010607835 cites W2009107648 @default.
• W2010607835 cites W2023859903 @default.
• W2010607835 cites W2024313361 @default.
• W2010607835 cites W2036287744 @default.
• W2010607835 cites W2037394705 @default.
• W2010607835 cites W2042176329 @default.
• W2010607835 cites W2053782858 @default.
• W2010607835 cites W2058680555 @default.
• W2010607835 cites W2064349365 @default.
• W2010607835 cites W2069534609 @default.
• W2010607835 cites W2070884732 @default.
• W2010607835 cites W2078627324 @default.
• W2010607835 cites W2084311974 @default.
• W2010607835 cites W2084707443 @default.
• W2010607835 cites W2106846696 @default.
• W2010607835 cites W2110042849 @default.
• W2010607835 cites W2122588714 @default.
• W2010607835 cites W2131062818 @default.
• W2010607835 cites W2131792565 @default.
• W2010607835 cites W2138454311 @default.
• W2010607835 cites W2146293179 @default.
• W2010607835 cites W2159874728 @default.
• W2010607835 cites W2165558354 @default.
• W2010607835 cites W2171717305 @default.
• W2010607835 cites W4230234871 @default.
• W2010607835 doi "https://doi.org/10.1016/j.ydbio.2007.04.042" @default.
• W2010607835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17583691" @default.
• W2010607835 hasPublicationYear "2007" @default.
• W2010607835 type Work @default.
• W2010607835 sameAs 2010607835 @default.
• W2010607835 citedByCount "131" @default.
• W2010607835 countsByYear W20106078352012 @default.
• W2010607835 countsByYear W20106078352013 @default.
• W2010607835 countsByYear W20106078352014 @default.
• W2010607835 countsByYear W20106078352015 @default.
• W2010607835 countsByYear W20106078352016 @default.
• W2010607835 countsByYear W20106078352017 @default.
• W2010607835 countsByYear W20106078352018 @default.
• W2010607835 countsByYear W20106078352019 @default.
• W2010607835 countsByYear W20106078352020 @default.
• W2010607835 countsByYear W20106078352021 @default.
• W2010607835 countsByYear W20106078352022 @default.
• W2010607835 countsByYear W20106078352023 @default.
• W2010607835 crossrefType "journal-article" @default.
• W2010607835 hasAuthorship W2010607835A5001813162 @default.
• W2010607835 hasAuthorship W2010607835A5036256585 @default.
• W2010607835 hasAuthorship W2010607835A5036881362 @default.
• W2010607835 hasAuthorship W2010607835A5037270460 @default.
• W2010607835 hasAuthorship W2010607835A5052067361 @default.
• W2010607835 hasAuthorship W2010607835A5056084313 @default.
• W2010607835 hasBestOaLocation W20106078351 @default.
• W2010607835 hasConcept C104317684 @default.
• W2010607835 hasConcept C126322002 @default.
• W2010607835 hasConcept C134018914 @default.
• W2010607835 hasConcept C142724271 @default.
• W2010607835 hasConcept C167734588 @default.
• W2010607835 hasConcept C170493617 @default.
• W2010607835 hasConcept C2776992346 @default.
• W2010607835 hasConcept C2776996007 @default.
• W2010607835 hasConcept C2777025900 @default.
• W2010607835 hasConcept C2777714996 @default.
• W2010607835 hasConcept C40692019 @default.
• W2010607835 hasConcept C502942594 @default.
• W2010607835 hasConcept C529295009 @default.
• W2010607835 hasConcept C54355233 @default.
• W2010607835 hasConcept C55493867 @default.
• W2010607835 hasConcept C71924100 @default.
• W2010607835 hasConcept C86803240 @default.
• W2010607835 hasConcept C87568996 @default.
• W2010607835 hasConcept C95444343 @default.
• W2010607835 hasConceptScore W2010607835C104317684 @default.
• W2010607835 hasConceptScore W2010607835C126322002 @default.
• W2010607835 hasConceptScore W2010607835C134018914 @default.
• W2010607835 hasConceptScore W2010607835C142724271 @default.

• next