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- W2010630369 abstract "Summary: The N-[(4-cycloheptylaminopyrid-3–yl)sulfonyl]-N′-cycloheptyl urea, a neuroprotective agent, and 10 chemically related sulfonyl(thio)ureas were evaluated in the maximal electroshock seizure test in mice. This sulfonylurea, BM 27, and two stucturally related sulfonylthioureas, BM 11 and BM 34, emerged with a 50% effective dose (ED50) of 2.87, 1.72, and 1.19 mg/kg, respectively. Their anticonvulsant profiles were found to be similar to that of phenytoin: active in the maximal electroshock seizure (MES) test and inactive in chemically induced seizures (pentetrazole, strychnine, bicuculline, picrotoxine, N-methyl-D,L-aspartic acid). These compounds exhibited a higher protective index and potency than those of phenytoin. Additional work remains necessary, however, to determine whether BM 27 is of clinical interest." @default.
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- W2010630369 date "1997-03-01" @default.
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- W2010630369 title "Anticonvulsant Activity of Pyrid-3-yl-Sulfonyl Ureas and Thioureas" @default.
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- W2010630369 doi "https://doi.org/10.1111/j.1528-1157.1997.tb01125.x" @default.
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