FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010632951> ?p ?o ?g. }

• W2010632951 endingPage "341" @default.
• W2010632951 startingPage "332" @default.
• W2010632951 abstract "Experimental right ventricular pressure-overload hypertrophy in small mammals is associated with early muscle dysfunction, even before the onset of overt pump failure. Experimental results are quite heterogeneous regarding muscle function of the pressure hypertrophied left ventricle. Muscle dysfunction of the right or left ventricle, when found, may be causally related to alterations of myosin ATPase activity and isozyme type. However, the effect of a gradual pressure overload, analogous to that which occurs in human aortic stenosis, on myocardial contractile function and myosin ATPase activity has not been studied in a large animal whose normal myosin isozyme pattern resembles that of man. We therefore studied pump performance, myocardial contractile function, and myosin ATPase activity and isozyme pattern in pigs with severe, gradually applied left ventricular pressure overload. Thirteen weeks after supravalvular aortic banding, 10 pigs grew more than 7-fold in body weight and were found to have an aortic stenosis area of 0.5 +/- 0.1 cm2 with a gradient of 93 +/- 12 mm Hg. Compared with nine control animals, the banded animals had a 67% increase in left ventricular mass relative to body weight without overt pump failure as measured by cardiac index and pulmonary artery wedge pressure. Left ventricular ejection performance, measured as shortening fraction, was maintained except in three animals with extreme hypertrophy, in which depressed ejection performance may have been due to an afterload mismatch, myocardial dysfunction, or both. Myocardial contractile function, determined from the end-systolic stress-diameter relationship, was normal except in two pigs in which ejection performance was depressed and left ventricular mass was more than doubled. Only the slow V3 isozyme of myosin ATPase was found in both normal and hypertrophied pig myocardium, and the ATPase activity was normal in pigs with all degrees of hypertrophy. Thus, in a large animal model of severe, gradual left ventricular pressure overload, in which myosin isozyme pattern remains apparently unaltered, moderate hypertrophy can be associated with normal myosin ATPase activity and contractile function that is normal by current methods of evaluation." @default.
• W2010632951 created "2016-06-24" @default.
• W2010632951 creator A5000521051 @default.
• W2010632951 creator A5013306631 @default.
• W2010632951 creator A5045861765 @default.
• W2010632951 creator A5060134886 @default.
• W2010632951 creator A5073331009 @default.
• W2010632951 creator A5088087979 @default.
• W2010632951 date "1983-09-01" @default.
• W2010632951 modified "2023-10-03" @default.
• W2010632951 title "Contractile function, myosin ATPase activity and isozymes in the hypertrophied pig left ventricle after a chronic progressive pressure overload." @default.
• W2010632951 cites W1481753986 @default.
• W2010632951 cites W188357701 @default.
• W2010632951 cites W1937764324 @default.
• W2010632951 cites W1971984246 @default.
• W2010632951 cites W1973040683 @default.
• W2010632951 cites W1978575714 @default.
• W2010632951 cites W1979900124 @default.
• W2010632951 cites W1989583421 @default.
• W2010632951 cites W1991882239 @default.
• W2010632951 cites W1992724992 @default.
• W2010632951 cites W2001342018 @default.
• W2010632951 cites W2009243683 @default.
• W2010632951 cites W2021027916 @default.
• W2010632951 cites W2023445437 @default.
• W2010632951 cites W2027555503 @default.
• W2010632951 cites W2028137315 @default.
• W2010632951 cites W2031753698 @default.
• W2010632951 cites W2032981883 @default.
• W2010632951 cites W2036973081 @default.
• W2010632951 cites W2038355279 @default.
• W2010632951 cites W2038889617 @default.
• W2010632951 cites W2047024906 @default.
• W2010632951 cites W2051293550 @default.
• W2010632951 cites W2054961027 @default.
• W2010632951 cites W2059322222 @default.
• W2010632951 cites W2063401784 @default.
• W2010632951 cites W2067161021 @default.
• W2010632951 cites W2072550665 @default.
• W2010632951 cites W2081590661 @default.
• W2010632951 cites W2091005514 @default.
• W2010632951 cites W2096636937 @default.
• W2010632951 cites W2100837269 @default.
• W2010632951 cites W2102923578 @default.
• W2010632951 cites W2104475665 @default.
• W2010632951 cites W2107572050 @default.
• W2010632951 cites W2108293623 @default.
• W2010632951 cites W2119229486 @default.
• W2010632951 cites W2121560256 @default.
• W2010632951 cites W2126593264 @default.
• W2010632951 cites W2145950740 @default.
• W2010632951 cites W2151844634 @default.
• W2010632951 cites W2153435210 @default.
• W2010632951 cites W2166627174 @default.
• W2010632951 cites W2204261915 @default.
• W2010632951 cites W2219775219 @default.
• W2010632951 cites W2336883536 @default.
• W2010632951 cites W2337579201 @default.
• W2010632951 cites W2401177394 @default.
• W2010632951 cites W4244844242 @default.
• W2010632951 doi "https://doi.org/10.1161/01.res.53.3.332" @default.
• W2010632951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6224606" @default.
• W2010632951 hasPublicationYear "1983" @default.
• W2010632951 type Work @default.
• W2010632951 sameAs 2010632951 @default.
• W2010632951 citedByCount "39" @default.
• W2010632951 countsByYear W20106329512012 @default.
• W2010632951 countsByYear W20106329512015 @default.
• W2010632951 countsByYear W20106329512016 @default.
• W2010632951 countsByYear W20106329512017 @default.
• W2010632951 countsByYear W20106329512018 @default.
• W2010632951 countsByYear W20106329512019 @default.
• W2010632951 countsByYear W20106329512022 @default.
• W2010632951 crossrefType "journal-article" @default.
• W2010632951 hasAuthorship W2010632951A5000521051 @default.
• W2010632951 hasAuthorship W2010632951A5013306631 @default.
• W2010632951 hasAuthorship W2010632951A5045861765 @default.
• W2010632951 hasAuthorship W2010632951A5060134886 @default.
• W2010632951 hasAuthorship W2010632951A5073331009 @default.
• W2010632951 hasAuthorship W2010632951A5088087979 @default.
• W2010632951 hasBestOaLocation W20106329511 @default.
• W2010632951 hasConcept C123576724 @default.
• W2010632951 hasConcept C12554922 @default.
• W2010632951 hasConcept C126322002 @default.
• W2010632951 hasConcept C134018914 @default.
• W2010632951 hasConcept C163415756 @default.
• W2010632951 hasConcept C164705383 @default.
• W2010632951 hasConcept C167414201 @default.
• W2010632951 hasConcept C26635844 @default.
• W2010632951 hasConcept C2778198053 @default.
• W2010632951 hasConcept C2778271984 @default.
• W2010632951 hasConcept C2778921608 @default.
• W2010632951 hasConcept C2780940725 @default.
• W2010632951 hasConcept C3018791406 @default.
• W2010632951 hasConcept C6997183 @default.
• W2010632951 hasConcept C71924100 @default.
• W2010632951 hasConcept C78085059 @default.
• W2010632951 hasConcept C84393581 @default.

• next