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• W2010642887 abstract "Le pourcentage d'enfants colonisés par S. pneumoniæ est dépendant de différents paramètres. Il est augmenté par le jeune âge des enfants, la garde en collectivité, la présence de frères et sœurs, les conditions socio-économiques défavorables, principalement la promiscuité, la saison et la présence d'une infection virale concomitante. L'antibiothérapie augmente le pourcentage de souches de sensibilité diminuée à la pénicilline. L'importance de tous ces facteurs dans la diffusion des souches de pneumocoques de sensibilité diminuée est illustrée par une étude du portage de S. pneumoniæ dans un orphelinat, réunissant de façon caricaturale tous ces facteurs de risque. Cette étude a montré que le portage est un processus dynamique qui évolue de façon séquentielle, chaque clone étant remplacé par un autre. Elle évoque le rôle du système immunitaire dans l'élimination de ces souches. Il s'agit d'une transmission de personne à personne plutôt que d'une colonisation de longue durée. Les souches sensibles à la pénicilline ne se sont jamais implantées dans cette communauté. Streptococcus pneumoniae is carried nasopharyngeally by 20 %–40 % of healthy children. But this rate of carriage is highly variable. Several risk factors have been associated with Streptococcus pneumoniae carriage, including day care center attendance, the size of the day care center, living in close contact as siblings, and socioeconomic factors. The antimicrobial treatment increases the percentage of penicillin-resistant Streptococcus pneumoniae . We report a prospective study on nasopharyngeal carriage of Streptococcus pneumoniae performed during a 1-year period in children living in an orphanage representing an extreme version of the situation of a day care center; 71 children (<24 months) were studied monthly. The mean rate of carriage was 57.4 % ranging from 42.8 % to 70.4 %, and 94.5 % of the isolates were resistant to penicillin. Children were sequentially colonized by a mean of 3 different isolates. Serotyping and molecular typing showed that children were colonized by a limited number of clones which rapidly spread in the community and colonized children in waves with a rapid turnover." @default.
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• W2010642887 date "2002-03-01" @default.
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• W2010642887 title "Facteurs influençant le portage de Streptococcus pneumoniæ" @default.
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• W2010642887 doi "https://doi.org/10.1016/s0399-077x(02)80003-8" @default.
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