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- W2010651617 abstract "Neuro/brain study has attracted much attention during past few years, and many optical methods have been utilized in order to obtain accurate and complete neural information inside the brain. Relying on simultaneous absorption of two or more near-infrared photons by a fluorophore, multiphoton microscopy can achieve deep tissue penetration and efficient light detection noninvasively, which makes it very suitable for thick-tissue and <i>in vivo</i> bioimaging. Nanoparticles possess many unique optical and chemical properties, such as anti-photobleaching, large multiphoton absorption cross-section, and high stability in biological environment, which facilitates their applications in long-term multiphoton microscopy as contrast agents. In this paper, we will introduce several typical nanoparticles (e.g. organic dye doped polymer nanoparticles and gold nanorods) with high multiphoton fluorescence efficiency. We further applied them in two- and three-photon <i>in vivo</i> functional brain imaging of mice, such as brain-microglia imaging, 3D architecture reconstruction of brain blood vessel, and blood velocity measurement." @default.
- W2010651617 created "2016-06-24" @default.
- W2010651617 creator A5017335487 @default.
- W2010651617 date "2015-03-10" @default.
- W2010651617 modified "2023-09-23" @default.
- W2010651617 title "Nanoparticle-assisted-multiphoton microscopy forin vivobrain imaging of mice" @default.
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- W2010651617 doi "https://doi.org/10.1117/12.2181331" @default.
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