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• W2010654750 abstract "Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and modifying the P2 side chain led to a metabolically robust inhibitor with a long half-life in preclinical species. Odanacatib was more selective in whole cell assays than the published Cat K inhibitors balicatib and relacatib. Evaluation in dermal fibroblast culture showed minimal intracellular collagen accumulation relative to less selective Cat K inhibitors." @default.
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• W2010654750 date "2008-02-01" @default.
• W2010654750 modified "2023-10-17" @default.
• W2010654750 title "The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K" @default.
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• W2010654750 doi "https://doi.org/10.1016/j.bmcl.2007.12.047" @default.
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