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• W2010654941 abstract "Two new phenanthrenequinones, calanquinones B and C (2 and 3) and four new 9,10-dihydrophenanthrenes, calanhydroquinones A−C (4−6) and calanphenanthrene A (7), along with five known compounds (1 and 8−11), were isolated from an EtOAc-soluble extract of Calanthe arisanensis through bioassay-guided fractionation. Their structures were identified from spectroscopic data, and the compounds were tested for in vitro cytotoxic activity against human lung (A549), prostate (PC-3 and DU145), colon (HCT-8), breast (MCF-7), nasopharyngeal (KB), and vincristine-resistant nasopharyngeal (KBVIN) cancer cell lines. Compound 1 showed the highest potency (EC50 < 0.5 μg/mL) against all seven cancer cell lines, with the greatest activity against breast cancer MCF-7 cells (EC50 < 0.02 μg/mL). Generally, except for 7, compounds 2−11 also showed significant cytotoxic activity (EC50 < 4 μg/mL) against some cell lines (especially PC-3 and MCF-7) in the panel." @default.
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• W2010654941 date "2009-02-04" @default.
• W2010654941 modified "2023-10-03" @default.
• W2010654941 title "Cytotoxic Phenanthrenequinones and 9,10-Dihydrophenanthrenes from <i>Calanthe arisanensis</i>" @default.
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• W2010654941 doi "https://doi.org/10.1021/np800622a" @default.
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