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- W2010657571 abstract "The objective of the present study was to assess the contribution of sodium influx to development of dark cell degeneration (DCD) in Purkinje neurons (PNs) following AMPA (dl-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid) receptor activation. During the course of these experiments, we observed inconsistent protection against DCD by Na+ ion substitutes leading us to consider other potential mechanisms. A 30 min application of AMPA (30 μM, induction or trigger phase) followed by a 90–120 min AMPA-free expression period produced DCD in the majority of PNs. Substitution of NaCl with choline chloride (120 mM) produced a marked suppression of AMPA-induced toxicity. Suppression of DCD by choline was concentration dependent. Concentrations of choline as low as 10 mM effectively attenuated DCD when substituted on an equimolar basis for NaCl in the artificial cerebrospinal fluid (ACSF). Unlike choline, substitution of NMDG for NaCl failed to suppress AMPA-induced DCD. Lidocaine and TTX (tetrodotoxin), two agents that inhibit Na+ influx failed to significantly alter DCD. Because choline is a prototypical α7 nicotinic receptor selective agonist, methyllycaconitine (MLA), an α7 receptor antagonist was tested and significantly attenuated the protective effects of choline in a concentration-dependent manner. Nicotine (100 μM) added to normal ACSF was effective in attenuating AMPA-induced toxicity. These findings suggest that DCD is not heavily dependent on Na+-mediated phenomena and that nicotinic α7 receptor activation may be neuroprotective against some types of excitotoxicity that are mediated by active cellular programs." @default.
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- W2010657571 date "2001-05-01" @default.
- W2010657571 modified "2023-10-14" @default.
- W2010657571 title "Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the α7 nicotinic receptor" @default.
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- W2010657571 doi "https://doi.org/10.1016/s0006-8993(01)02270-3" @default.
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