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• W2010658411 abstract "microRNAs (miRNAs) represent a class of small (typically 22 nucleotides in length) non-coding RNAs that can degrade their target mRNAs or block their translation. Recent research showed that copy number alterations of miRNAs and their target genes are highly prevalent in cancers; however, the evolutionary and biological functions of naturally existing copy number variable miRNAs (CNV-miRNAs) among individuals have not been studied extensively throughout the genome.In this study, we comprehensively analyzed the properties of genes regulated by CNV-miRNAs, and found that CNV-miRNAs tend to target a higher average number of genes and prefer to synergistically regulate the same genes; further, the targets of CNV-miRNAs tend to have higher variability of expression within and between populations. Finally, we found the targets of CNV-miRNAs are more likely to be differentially expressed among tissues and developmental stages, and participate in a wide range of cellular responses.Our analyses of CNV-miRNAs provide new insights into the impact of copy number variations on miRNA-mediated post-transcriptional networks. The deeper interpretation of patterns of gene expression variation and the functional characterization of CNV-miRNAs will help to broaden the current understanding of the molecular basis of human phenotypic diversity." @default.
• W2010658411 created "2016-06-24" @default.
• W2010658411 creator A5013178268 @default.
• W2010658411 creator A5039279042 @default.
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• W2010658411 date "2012-12-01" @default.
• W2010658411 modified "2023-10-10" @default.
• W2010658411 title "Insights into the regulation of human CNV-miRNAs from the view of their target genes" @default.
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• W2010658411 doi "https://doi.org/10.1186/1471-2164-13-707" @default.
• W2010658411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582595" @default.
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