Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010658627> ?p ?o ?g. }
- W2010658627 endingPage "134" @default.
- W2010658627 startingPage "122" @default.
- W2010658627 abstract "IN 1906 extracts of mucosa from the upper small intestine from pigs were tested as a treatment of diabetes in the hope that “the internal secretion of the pancreas might be stimulated and initiated by the substance of the nature of a hormone yielded by the duodenal mucous membrane” (1). La Barre (2) introduced the name incretin for an unidentified substance that was thought to exert this effect. With the advent of insulin RIAs in the early 1960s (3), it was shown that insulin levels in the blood after ingestion of glucose were elevated out of proportion to the concentration of blood glucose when compared with the response to glucose given iv (4, 5). It was suggested that the potentiation of insulin secretion after oral glucose was mediated by a humoral substance which was released from the gut during glucose absorption and which stimulated insulin secretion (4, 5). Some years later a polypeptide was found (6, 7), which, due to its inhibitory effect on gastric acid secretion in dogs (8), was named gastric inhibitory polypeptide (GIP) (6, 7). Intravenous infusion of natural porcine GIP significantly enhanced serum immunoreactive insulin (IRI) and improved glucose tolerance after iv glucose in man (9). Later studies showed that GIP was insulinotropic only at glucose concentrations above 5.5–6.0 mmol/liter (10–12), and it was suggested that GIP should be renamed glucose-dependent insulinotropic polypeptide (13). There is, however, no general agreement to this new designation so the original name will be used throughout this review. Today GIP is considered to be the most important incretin factor (14–16), whereas the inhibitory effect of GIP on gastric acid secretion in normal subjects has been questioned (15)." @default.
- W2010658627 created "2016-06-24" @default.
- W2010658627 creator A5018061859 @default.
- W2010658627 date "1988-02-01" @default.
- W2010658627 modified "2023-10-16" @default.
- W2010658627 title "Immunoreactive Gastric Inhibitory Polypeptide*" @default.
- W2010658627 cites W1270261677 @default.
- W2010658627 cites W152229969 @default.
- W2010658627 cites W1898361529 @default.
- W2010658627 cites W1965799264 @default.
- W2010658627 cites W1966573520 @default.
- W2010658627 cites W1966786964 @default.
- W2010658627 cites W1968084470 @default.
- W2010658627 cites W1969480413 @default.
- W2010658627 cites W1969914692 @default.
- W2010658627 cites W1971990975 @default.
- W2010658627 cites W1972481662 @default.
- W2010658627 cites W1974554536 @default.
- W2010658627 cites W1975894647 @default.
- W2010658627 cites W1976509913 @default.
- W2010658627 cites W1983441757 @default.
- W2010658627 cites W1983867808 @default.
- W2010658627 cites W1984567330 @default.
- W2010658627 cites W1989926333 @default.
- W2010658627 cites W1994989824 @default.
- W2010658627 cites W1997505976 @default.
- W2010658627 cites W1999242098 @default.
- W2010658627 cites W2004803648 @default.
- W2010658627 cites W2007621981 @default.
- W2010658627 cites W2007723353 @default.
- W2010658627 cites W2008635588 @default.
- W2010658627 cites W2012223202 @default.
- W2010658627 cites W2014278919 @default.
- W2010658627 cites W2015606003 @default.
- W2010658627 cites W2020985963 @default.
- W2010658627 cites W2027434254 @default.
- W2010658627 cites W2028319437 @default.
- W2010658627 cites W2028431435 @default.
- W2010658627 cites W2028789679 @default.
- W2010658627 cites W2030732261 @default.
- W2010658627 cites W2031820400 @default.
- W2010658627 cites W2032731213 @default.
- W2010658627 cites W2033322586 @default.
- W2010658627 cites W2034827963 @default.
- W2010658627 cites W2037484950 @default.
- W2010658627 cites W2037839438 @default.
- W2010658627 cites W2042010395 @default.
- W2010658627 cites W2044893525 @default.
- W2010658627 cites W2046155875 @default.
- W2010658627 cites W2047022776 @default.
- W2010658627 cites W2049616017 @default.
- W2010658627 cites W2051743127 @default.
- W2010658627 cites W2052799995 @default.
- W2010658627 cites W2053814224 @default.
- W2010658627 cites W2054564814 @default.
- W2010658627 cites W2055153265 @default.
- W2010658627 cites W2055404782 @default.
- W2010658627 cites W2055917708 @default.
- W2010658627 cites W2067643934 @default.
- W2010658627 cites W2068166803 @default.
- W2010658627 cites W2070070451 @default.
- W2010658627 cites W2072902133 @default.
- W2010658627 cites W2072919243 @default.
- W2010658627 cites W2073177332 @default.
- W2010658627 cites W2075404533 @default.
- W2010658627 cites W2075625173 @default.
- W2010658627 cites W2081101301 @default.
- W2010658627 cites W2082850586 @default.
- W2010658627 cites W2082961743 @default.
- W2010658627 cites W2086466242 @default.
- W2010658627 cites W2087918129 @default.
- W2010658627 cites W2089557095 @default.
- W2010658627 cites W2089734083 @default.
- W2010658627 cites W2094128609 @default.
- W2010658627 cites W2094262609 @default.
- W2010658627 cites W2095584583 @default.
- W2010658627 cites W2101425299 @default.
- W2010658627 cites W2102977341 @default.
- W2010658627 cites W2104162165 @default.
- W2010658627 cites W2105912552 @default.
- W2010658627 cites W2107757312 @default.
- W2010658627 cites W2110375524 @default.
- W2010658627 cites W2110596588 @default.
- W2010658627 cites W2113532020 @default.
- W2010658627 cites W2114583988 @default.
- W2010658627 cites W2115306377 @default.
- W2010658627 cites W2116350853 @default.
- W2010658627 cites W2116739144 @default.
- W2010658627 cites W2124398468 @default.
- W2010658627 cites W2125820220 @default.
- W2010658627 cites W2126370453 @default.
- W2010658627 cites W2126918525 @default.
- W2010658627 cites W2139470767 @default.
- W2010658627 cites W2147817624 @default.
- W2010658627 cites W2161599789 @default.
- W2010658627 cites W2163235578 @default.
- W2010658627 cites W2170599934 @default.
- W2010658627 cites W2171377785 @default.