Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010659743> ?p ?o ?g. }
- W2010659743 abstract "Translationally controlled tumor protein (TCTP), is a highly conserved protein involved in fundamental processes, such as cell proliferation and growth, tumorigenesis, apoptosis, pluripotency and cell cycle regulation. TCTP also inhibits Na,K-ATPase whose subunits have been suggested as a marker of epithelial-to-mesenchymal transition (EMT), a crucial step during tumor invasiveness, metastasis and fibrosis. We hypothesized that, TCTP might also serve as an EMT inducer. This study attempts to verify this hypothesis. We found that overexpression of TCTP in a porcine renal proximal tubule cell line, LLC-PK1, induced EMT-like phenotypes with the expected morphological changes and appearance of EMT related markers. Conversely, depletion of TCTP reversed the induction of these EMT phenotypes. TCTP overexpression also enhanced cell migration via activation of mTORC2/Akt/GSK3β/β-catenin and invasiveness by activating MMP-9. Moreover, TCTP depletion in melanoma cells significantly reduced pulmonary metastasis by inhibiting the development of mesenchymal-like phenotypes. Overall, these findings support our hypothesis that TCTP is a positive regulator of EMT and suggest that modulation of TCTP expression is a potential approach to inhibit the invasiveness and migration of cancer cells and the attendant pathologic processes including metastasis." @default.
- W2010659743 created "2016-06-24" @default.
- W2010659743 creator A5031370310 @default.
- W2010659743 creator A5062607213 @default.
- W2010659743 creator A5073384154 @default.
- W2010659743 creator A5079735717 @default.
- W2010659743 date "2015-01-27" @default.
- W2010659743 modified "2023-10-18" @default.
- W2010659743 title "Translationally Controlled Tumor Protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis" @default.
- W2010659743 cites W1484020898 @default.
- W2010659743 cites W1951049964 @default.
- W2010659743 cites W1963681491 @default.
- W2010659743 cites W1966156998 @default.
- W2010659743 cites W1967532587 @default.
- W2010659743 cites W1971330033 @default.
- W2010659743 cites W1974248736 @default.
- W2010659743 cites W1977352336 @default.
- W2010659743 cites W1978458659 @default.
- W2010659743 cites W1979988883 @default.
- W2010659743 cites W1980667399 @default.
- W2010659743 cites W1984621921 @default.
- W2010659743 cites W1985066088 @default.
- W2010659743 cites W1989769592 @default.
- W2010659743 cites W1999720300 @default.
- W2010659743 cites W2006559495 @default.
- W2010659743 cites W2007724985 @default.
- W2010659743 cites W2009111926 @default.
- W2010659743 cites W2012865029 @default.
- W2010659743 cites W2013524931 @default.
- W2010659743 cites W2014521942 @default.
- W2010659743 cites W2030699054 @default.
- W2010659743 cites W2036839927 @default.
- W2010659743 cites W2047750593 @default.
- W2010659743 cites W2050089891 @default.
- W2010659743 cites W2052251250 @default.
- W2010659743 cites W2061847701 @default.
- W2010659743 cites W2061947512 @default.
- W2010659743 cites W2063426918 @default.
- W2010659743 cites W2064717188 @default.
- W2010659743 cites W2065887259 @default.
- W2010659743 cites W2077462602 @default.
- W2010659743 cites W2078576765 @default.
- W2010659743 cites W2080232352 @default.
- W2010659743 cites W2083297935 @default.
- W2010659743 cites W2086850005 @default.
- W2010659743 cites W2102175027 @default.
- W2010659743 cites W2104692426 @default.
- W2010659743 cites W2116672575 @default.
- W2010659743 cites W2119065397 @default.
- W2010659743 cites W2122693202 @default.
- W2010659743 cites W2127357183 @default.
- W2010659743 cites W2129585918 @default.
- W2010659743 cites W2131707609 @default.
- W2010659743 cites W2135723119 @default.
- W2010659743 cites W2139474178 @default.
- W2010659743 cites W2140551998 @default.
- W2010659743 cites W2143824937 @default.
- W2010659743 cites W2146157811 @default.
- W2010659743 cites W2152289580 @default.
- W2010659743 cites W2154589460 @default.
- W2010659743 cites W2159330672 @default.
- W2010659743 cites W2163576510 @default.
- W2010659743 cites W2166648052 @default.
- W2010659743 cites W2167158605 @default.
- W2010659743 cites W4238567307 @default.
- W2010659743 cites W4252987835 @default.
- W2010659743 doi "https://doi.org/10.1038/srep08061" @default.
- W2010659743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4306963" @default.
- W2010659743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25622969" @default.
- W2010659743 hasPublicationYear "2015" @default.
- W2010659743 type Work @default.
- W2010659743 sameAs 2010659743 @default.
- W2010659743 citedByCount "49" @default.
- W2010659743 countsByYear W20106597432015 @default.
- W2010659743 countsByYear W20106597432016 @default.
- W2010659743 countsByYear W20106597432017 @default.
- W2010659743 countsByYear W20106597432018 @default.
- W2010659743 countsByYear W20106597432019 @default.
- W2010659743 countsByYear W20106597432020 @default.
- W2010659743 countsByYear W20106597432021 @default.
- W2010659743 countsByYear W20106597432022 @default.
- W2010659743 countsByYear W20106597432023 @default.
- W2010659743 crossrefType "journal-article" @default.
- W2010659743 hasAuthorship W2010659743A5031370310 @default.
- W2010659743 hasAuthorship W2010659743A5062607213 @default.
- W2010659743 hasAuthorship W2010659743A5073384154 @default.
- W2010659743 hasAuthorship W2010659743A5079735717 @default.
- W2010659743 hasBestOaLocation W20106597431 @default.
- W2010659743 hasConcept C121608353 @default.
- W2010659743 hasConcept C137738243 @default.
- W2010659743 hasConcept C1491633281 @default.
- W2010659743 hasConcept C2779013556 @default.
- W2010659743 hasConcept C502942594 @default.
- W2010659743 hasConcept C54355233 @default.
- W2010659743 hasConcept C555283112 @default.
- W2010659743 hasConcept C62112901 @default.
- W2010659743 hasConcept C62478195 @default.
- W2010659743 hasConcept C75217442 @default.
- W2010659743 hasConcept C76419328 @default.
- W2010659743 hasConcept C86554907 @default.