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• W2010667348 endingPage "1053" @default.
• W2010667348 startingPage "1045" @default.
• W2010667348 abstract "Abstract Resonance Raman spectra are reported for substrate‐free and camphor‐bound cytochrome P450cam and its isotopically labeled analogues that have been reconstituted with protoheme derivatives that bear ‐CD 3 groups at the 1, 3, 5, and 8‐positions (d12‐protoheme) or deuterated methine carbons (d4‐protoheme). In agreement with previous studies of this and similar enzymes, substrate binding induces changes in the high frequency and low frequency spectral regions, with the most dramatic effect in the low frequency region being activation of a new mode near 367 cm −1 . This substrate‐activated mode had been previously assigned as a second “propionate bending” mode (Chen et al., Biochemistry, 2004, 43, 1798–1808), arising in addition to the single propionate bending mode observed for the substrate‐free form at 380 cm −1 . In this work, this newly activated mode is observed to shift by 8 cm −1 to lower frequency in the d12‐protoheme reconstituted enzyme (i.e., the same shift as that observed for the higher frequency “propionate bending” mode) and is therefore consistent with the suggested assignment. However, the newly acquired data for the d4‐protoheme substituted analogue also support an earlier alternate suggestion (Deng et al., Biochemistry, 1999, 38, 13699–13706) that substrate binding activates several heme out‐of‐plane modes, one of which (γ 6 ) is accidentally degenerate with the 367 cm −1 propionate bending mode. Finally, the study of the enzyme reconstituted with the protoheme‐d4, which shifts the macrocycle ν 10 mode, has now allowed a definitive identification of the vinyl CC stretching modes. © 2008 Wiley Periodicals, Inc. Biopolymers 89: 1045–1053, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com" @default.
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• W2010667348 date "2008-07-24" @default.
• W2010667348 modified "2023-10-18" @default.
• W2010667348 title "Defining resonance Raman spectral responses to substrate binding by cytochrome P450 from<i>Pseudomonas putida</i>" @default.
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• W2010667348 doi "https://doi.org/10.1002/bip.21058" @default.
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