FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010670898> ?p ?o ?g. }

• W2010670898 endingPage "1033" @default.
• W2010670898 startingPage "1027" @default.
• W2010670898 abstract "We studied the effect of MgADP on the mechanical interaction of actomyosin in cardiac and skeletal muscles using an in vitro motility assay. The sliding velocities of fluorescently labeled actin filaments on rat cardiac and skeletal myosins were measured at various MgATP and MgADP concentrations. The filament velocity depended on MgATP concentration according to classic Michaelis-Menten kinetics with apparent Michaelis constants (Km) of 43 and 137 mumol/L and maximum velocity of 5.6 and 8.6 microns/s for cardiac and skeletal myosins, respectively. The presence of 2 mmol/L MgADP decreased the filament velocity and shifted the substrate concentration dependence of the velocity toward higher MgATP concentrations, yielding the inhibition constants of 194 and 478 mumol/L for cardiac and skeletal myosins, respectively. The activation energies determined by the temperature dependence of the velocity were 61 and 83 kJ/mol for rat V1 and rabbit cardiac myosins, which were similar to those of the dissociation rate constant of actomyosin-ADP complex reported in a solution study. The inhibition of the velocity by MgADP can be explained by the crossbridge scheme in which MgADP competes with MgATP for the substrate site on myosin molecules. In cardiac myosin, addition of a concentration of MgADP as low as 25 mumol/L significantly inhibited the velocity in the presence of 2 mmol/L MgATP, suggesting that increased intracellular MgADP may reduce the rate of crossbridge detachment, resulting in a decreased ATP consumption and an increased economy of force production under ischemic conditions. The present results support the idea that MgADP may be a physiologically important modulator of contraction in cardiac muscle." @default.
• W2010670898 created "2016-06-24" @default.
• W2010670898 creator A5015161467 @default.
• W2010670898 creator A5048761504 @default.
• W2010670898 creator A5053906986 @default.
• W2010670898 creator A5055654727 @default.
• W2010670898 creator A5055876250 @default.
• W2010670898 creator A5070432957 @default.
• W2010670898 date "1994-06-01" @default.
• W2010670898 modified "2023-10-10" @default.
• W2010670898 title "ADP inhibits the sliding velocity of fluorescent actin filaments on cardiac and skeletal myosins." @default.
• W2010670898 cites W1535644751 @default.
• W2010670898 cites W1536215014 @default.
• W2010670898 cites W1538692246 @default.
• W2010670898 cites W1775749144 @default.
• W2010670898 cites W1971274190 @default.
• W2010670898 cites W1977051351 @default.
• W2010670898 cites W1981513138 @default.
• W2010670898 cites W1993512663 @default.
• W2010670898 cites W1993615583 @default.
• W2010670898 cites W1996595428 @default.
• W2010670898 cites W1997688907 @default.
• W2010670898 cites W2000773216 @default.
• W2010670898 cites W2022719895 @default.
• W2010670898 cites W2025884869 @default.
• W2010670898 cites W2026145805 @default.
• W2010670898 cites W2026836008 @default.
• W2010670898 cites W2028207310 @default.
• W2010670898 cites W2030547704 @default.
• W2010670898 cites W2051146620 @default.
• W2010670898 cites W2052976658 @default.
• W2010670898 cites W2060683667 @default.
• W2010670898 cites W2061919351 @default.
• W2010670898 cites W2075057480 @default.
• W2010670898 cites W2076559561 @default.
• W2010670898 cites W2077999459 @default.
• W2010670898 cites W2084574820 @default.
• W2010670898 cites W2104465251 @default.
• W2010670898 cites W2122933457 @default.
• W2010670898 cites W2140994672 @default.
• W2010670898 cites W2151808726 @default.
• W2010670898 cites W2332364831 @default.
• W2010670898 cites W2419202274 @default.
• W2010670898 cites W82303313 @default.
• W2010670898 doi "https://doi.org/10.1161/01.res.74.6.1027" @default.
• W2010670898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8187272" @default.
• W2010670898 hasPublicationYear "1994" @default.
• W2010670898 type Work @default.
• W2010670898 sameAs 2010670898 @default.
• W2010670898 citedByCount "50" @default.
• W2010670898 countsByYear W20106708982012 @default.
• W2010670898 countsByYear W20106708982013 @default.
• W2010670898 countsByYear W20106708982014 @default.
• W2010670898 countsByYear W20106708982015 @default.
• W2010670898 countsByYear W20106708982016 @default.
• W2010670898 countsByYear W20106708982017 @default.
• W2010670898 countsByYear W20106708982019 @default.
• W2010670898 countsByYear W20106708982021 @default.
• W2010670898 countsByYear W20106708982022 @default.
• W2010670898 crossrefType "journal-article" @default.
• W2010670898 hasAuthorship W2010670898A5015161467 @default.
• W2010670898 hasAuthorship W2010670898A5048761504 @default.
• W2010670898 hasAuthorship W2010670898A5053906986 @default.
• W2010670898 hasAuthorship W2010670898A5055654727 @default.
• W2010670898 hasAuthorship W2010670898A5055876250 @default.
• W2010670898 hasAuthorship W2010670898A5070432957 @default.
• W2010670898 hasBestOaLocation W20106708981 @default.
• W2010670898 hasConcept C105702510 @default.
• W2010670898 hasConcept C12554922 @default.
• W2010670898 hasConcept C125705527 @default.
• W2010670898 hasConcept C14228908 @default.
• W2010670898 hasConcept C170493617 @default.
• W2010670898 hasConcept C185592680 @default.
• W2010670898 hasConcept C18903297 @default.
• W2010670898 hasConcept C2776329151 @default.
• W2010670898 hasConcept C2777289219 @default.
• W2010670898 hasConcept C2778996579 @default.
• W2010670898 hasConcept C2779564974 @default.
• W2010670898 hasConcept C2779959927 @default.
• W2010670898 hasConcept C55493867 @default.
• W2010670898 hasConcept C6997183 @default.
• W2010670898 hasConcept C74998103 @default.
• W2010670898 hasConcept C79879829 @default.
• W2010670898 hasConcept C86803240 @default.
• W2010670898 hasConceptScore W2010670898C105702510 @default.
• W2010670898 hasConceptScore W2010670898C12554922 @default.
• W2010670898 hasConceptScore W2010670898C125705527 @default.
• W2010670898 hasConceptScore W2010670898C14228908 @default.
• W2010670898 hasConceptScore W2010670898C170493617 @default.
• W2010670898 hasConceptScore W2010670898C185592680 @default.
• W2010670898 hasConceptScore W2010670898C18903297 @default.
• W2010670898 hasConceptScore W2010670898C2776329151 @default.
• W2010670898 hasConceptScore W2010670898C2777289219 @default.
• W2010670898 hasConceptScore W2010670898C2778996579 @default.
• W2010670898 hasConceptScore W2010670898C2779564974 @default.
• W2010670898 hasConceptScore W2010670898C2779959927 @default.
• W2010670898 hasConceptScore W2010670898C55493867 @default.
• W2010670898 hasConceptScore W2010670898C6997183 @default.

• next