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• W2010671489 abstract "Insulin resistance and type 2 diabetes mellitus are associated with impaired postprandial secretion of glucagon-like peptide-1 (GLP-1), a potent insulinotropic hormone. The direct effects of insulin and insulin resistance on the L cell are unknown. We therefore hypothesized that the L cell is responsive to insulin and that insulin resistance impairs GLP-1 secretion. The effects of insulin and insulin resistance were examined in well-characterized L cell models: murine GLUTag, human NCI-H716, and fetal rat intestinal cells. MKR mice, a model of chronic hyperinsulinemia, were used to assess the function of the L cell in vivo. In all cells, insulin activated the phosphatidylinositol 3 kinase-Akt and MAPK kinase (MEK)-ERK1/2 pathways and stimulated GLP-1 secretion by up to 275 +/- 58%. Insulin resistance was induced by 24 h pretreatment with 10(-7) m insulin, causing a marked reduction in activation of Akt and ERK1/2. Furthermore, both insulin-induced GLP-1 release and secretion in response to glucose-dependent insulinotropic peptide and phorbol-12-myristate-13-acetate were significantly attenuated. Whereas inhibition of phosphatidylinositol 3 kinase with LY294002 potentiated insulin-induced GLP-1 release, secretion was abrogated by inhibiting the MEK-ERK1/2 pathway with PD98059 or by overexpression of a kinase-dead MEK1-ERK2 fusion protein. Compared with controls, MKR mice were insulin resistant and displayed significantly higher fasting plasma insulin levels. Furthermore, they had significantly higher basal GLP-1 levels but displayed impaired GLP-1 secretion after an oral glucose challenge. These findings indicate that the intestinal L cell is responsive to insulin and that insulin resistance in vitro and in vivo is associated with impaired GLP-1 secretion." @default.
• W2010671489 created "2016-06-24" @default.
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• W2010671489 date "2009-02-01" @default.
• W2010671489 modified "2023-10-17" @default.
• W2010671489 title "Insulin Regulates Glucagon-Like Peptide-1 Secretion from the Enteroendocrine L Cell" @default.
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• W2010671489 cites W1976980904 @default.
• W2010671489 cites W1977226383 @default.
• W2010671489 cites W1980143749 @default.
• W2010671489 cites W1983284877 @default.
• W2010671489 cites W1984600798 @default.
• W2010671489 cites W1986420181 @default.
• W2010671489 cites W1991698362 @default.
• W2010671489 cites W1994141137 @default.
• W2010671489 cites W1995482720 @default.
• W2010671489 cites W1995527150 @default.
• W2010671489 cites W1995646241 @default.
• W2010671489 cites W1996046875 @default.
• W2010671489 cites W1996839988 @default.
• W2010671489 cites W1996872860 @default.
• W2010671489 cites W2004891119 @default.
• W2010671489 cites W2005657338 @default.
• W2010671489 cites W2020477537 @default.
• W2010671489 cites W2024317462 @default.
• W2010671489 cites W2024409703 @default.
• W2010671489 cites W2027009452 @default.
• W2010671489 cites W2028744189 @default.
• W2010671489 cites W2032225465 @default.
• W2010671489 cites W2032322539 @default.
• W2010671489 cites W2033904567 @default.
• W2010671489 cites W2033910639 @default.
• W2010671489 cites W2035530115 @default.
• W2010671489 cites W2041150765 @default.
• W2010671489 cites W2047022776 @default.
• W2010671489 cites W2048352852 @default.
• W2010671489 cites W2048876290 @default.
• W2010671489 cites W2062420102 @default.
• W2010671489 cites W2073327313 @default.
• W2010671489 cites W2074441235 @default.
• W2010671489 cites W2081666098 @default.
• W2010671489 cites W2089304685 @default.
• W2010671489 cites W2090802509 @default.
• W2010671489 cites W2091545863 @default.
• W2010671489 cites W2100126797 @default.
• W2010671489 cites W2100811284 @default.
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• W2010671489 cites W2108046960 @default.
• W2010671489 cites W2109192263 @default.
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• W2010671489 cites W2125231550 @default.
• W2010671489 cites W2126032145 @default.
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• W2010671489 cites W2146581079 @default.
• W2010671489 cites W2147216118 @default.
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• W2010671489 doi "https://doi.org/10.1210/en.2008-0726" @default.
• W2010671489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5393261" @default.
• W2010671489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18818290" @default.
• W2010671489 hasPublicationYear "2009" @default.
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