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- W2010672309 abstract "Summary Background : In patients with Helicobacter pylori infection, the concentration of nitrite in gastric juice is elevated. The degree of elevation correlates with that of inflammation and H. pylori density. Aim : The aim of this study was to examine hypoacidity and high nitrite levels related to H. pylori infection in patients with gastric cancer. Methods : We studied 88 patients with more than one history of endoscopic mucosal resection (EMR) for early gastric cancer and 88 age‐matched controls. C oncentration of nitrite in gastric juice was measured by Griess reaction, and serum pepsinogen levels were measured by RIA. Results : Multiple malignant lesions were found in 20 of the 88 patients. Serum gastrin, gastric juice pH and nitrite levels in patients with gastric cancer were significantly higher and pepsinogen I and pepsinogen I/II significantly lower than in control subjects. Pepsinogen I level and I/II ratio were lower and gastric juice pH was higher in the protruded‐type group than in the depressed‐type group. Pepsinogen I and pepsinogen I/II were lower and gastric juice pH was higher in multiple than in single cases. Conclusions : Hypoacidity combined with high gastric juice nitrite induced by H. pylori infection is associated with the intestinal type of gastric cancer, especially protruded lesions." @default.
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- W2010672309 date "2004-07-01" @default.
- W2010672309 modified "2023-10-17" @default.
- W2010672309 title "Hypoacidity combined with high gastric juice nitrite induced by <i>Helicobacter pylori</i> infection is associated with gastric cancer" @default.
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- W2010672309 doi "https://doi.org/10.1111/j.1365-2036.2004.01978.x" @default.
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