FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010675445> ?p ?o ?g. }

• W2010675445 endingPage "96" @default.
• W2010675445 startingPage "90" @default.
• W2010675445 abstract "A new in vivo model for studying luteolysis was developed in sheep to provide a convenient method for collecting corpora lutea for molecular, biochemical, and histological analysis during a procedure that mimics natural luteolysis. It was found that the infusion of prostaglandin F(2α) (PGF(2α)) at 20 μg/min/h into the systemic circulation during the mid luteal phase of the cycle allowed sufficient PGF(2α) to escape across the lungs and thus mimic the transient 40% decline in the concentration of progesterone in peripheral plasma seen at the onset of natural luteolysis in sheep. Additional 1h-long systemic infusions of PGF(2α), given at physiological intervals, indicated that two infusions were not sufficient to induce luteolysis. However, an early onset of luteolysis and estrus was induced in one out of three sheep with three infusions, two out of three sheep with four infusions, and three out of three sheep with five infusions. Reducing the duration of each systemic infusion of PGF(2α) from 1h to 30 min failed to induce luteolysis and estrus even after six systemic infusions indicating that, not only are the amplitude and frequency of PGF(2α) pulses essential for luteolysis, but the actual duration of each pulse is also critical. We conclude that a minimum of five systemic pulses of PGF(2α), given in an appropriate amount and at a physiological frequency and duration, are required to mimic luteolysis consistently in all sheep. The five pulse regimen thus provides a new accurate in vivo model for studying molecular mechanisms of luteolysis." @default.
• W2010675445 created "2016-06-24" @default.
• W2010675445 creator A5009081735 @default.
• W2010675445 creator A5019338672 @default.
• W2010675445 creator A5037661412 @default.
• W2010675445 creator A5043762829 @default.
• W2010675445 creator A5048829105 @default.
• W2010675445 creator A5058211673 @default.
• W2010675445 date "2012-03-01" @default.
• W2010675445 modified "2023-09-24" @default.
• W2010675445 title "A new in vivo model for luteolysis using systemic pulsatile infusions of PGF2α" @default.
• W2010675445 cites W1621060631 @default.
• W2010675445 cites W1976190649 @default.
• W2010675445 cites W1986884292 @default.
• W2010675445 cites W1989250297 @default.
• W2010675445 cites W2002497773 @default.
• W2010675445 cites W2039616023 @default.
• W2010675445 cites W2041276572 @default.
• W2010675445 cites W2043000172 @default.
• W2010675445 cites W2047438600 @default.
• W2010675445 cites W2053784946 @default.
• W2010675445 cites W2060541214 @default.
• W2010675445 cites W2086910152 @default.
• W2010675445 cites W2099428304 @default.
• W2010675445 cites W2114605096 @default.
• W2010675445 cites W2116883094 @default.
• W2010675445 cites W2138071010 @default.
• W2010675445 cites W2181983966 @default.
• W2010675445 cites W223568095 @default.
• W2010675445 cites W253642005 @default.
• W2010675445 cites W90866616 @default.
• W2010675445 doi "https://doi.org/10.1016/j.prostaglandins.2012.01.004" @default.
• W2010675445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22300963" @default.
• W2010675445 hasPublicationYear "2012" @default.
• W2010675445 type Work @default.
• W2010675445 sameAs 2010675445 @default.
• W2010675445 citedByCount "13" @default.
• W2010675445 countsByYear W20106754452012 @default.
• W2010675445 countsByYear W20106754452013 @default.
• W2010675445 countsByYear W20106754452014 @default.
• W2010675445 countsByYear W20106754452015 @default.
• W2010675445 countsByYear W20106754452016 @default.
• W2010675445 countsByYear W20106754452017 @default.
• W2010675445 countsByYear W20106754452019 @default.
• W2010675445 countsByYear W20106754452021 @default.
• W2010675445 countsByYear W20106754452022 @default.
• W2010675445 crossrefType "journal-article" @default.
• W2010675445 hasAuthorship W2010675445A5009081735 @default.
• W2010675445 hasAuthorship W2010675445A5019338672 @default.
• W2010675445 hasAuthorship W2010675445A5037661412 @default.
• W2010675445 hasAuthorship W2010675445A5043762829 @default.
• W2010675445 hasAuthorship W2010675445A5048829105 @default.
• W2010675445 hasAuthorship W2010675445A5058211673 @default.
• W2010675445 hasConcept C119599485 @default.
• W2010675445 hasConcept C126322002 @default.
• W2010675445 hasConcept C127413603 @default.
• W2010675445 hasConcept C134018914 @default.
• W2010675445 hasConcept C143228043 @default.
• W2010675445 hasConcept C150903083 @default.
• W2010675445 hasConcept C1998276 @default.
• W2010675445 hasConcept C207001950 @default.
• W2010675445 hasConcept C26291073 @default.
• W2010675445 hasConcept C2776165368 @default.
• W2010675445 hasConcept C2777330693 @default.
• W2010675445 hasConcept C2780167933 @default.
• W2010675445 hasConcept C2780664492 @default.
• W2010675445 hasConcept C71315377 @default.
• W2010675445 hasConcept C71924100 @default.
• W2010675445 hasConcept C79191276 @default.
• W2010675445 hasConcept C86803240 @default.
• W2010675445 hasConcept C94915269 @default.
• W2010675445 hasConceptScore W2010675445C119599485 @default.
• W2010675445 hasConceptScore W2010675445C126322002 @default.
• W2010675445 hasConceptScore W2010675445C127413603 @default.
• W2010675445 hasConceptScore W2010675445C134018914 @default.
• W2010675445 hasConceptScore W2010675445C143228043 @default.
• W2010675445 hasConceptScore W2010675445C150903083 @default.
• W2010675445 hasConceptScore W2010675445C1998276 @default.
• W2010675445 hasConceptScore W2010675445C207001950 @default.
• W2010675445 hasConceptScore W2010675445C26291073 @default.
• W2010675445 hasConceptScore W2010675445C2776165368 @default.
• W2010675445 hasConceptScore W2010675445C2777330693 @default.
• W2010675445 hasConceptScore W2010675445C2780167933 @default.
• W2010675445 hasConceptScore W2010675445C2780664492 @default.
• W2010675445 hasConceptScore W2010675445C71315377 @default.
• W2010675445 hasConceptScore W2010675445C71924100 @default.
• W2010675445 hasConceptScore W2010675445C79191276 @default.
• W2010675445 hasConceptScore W2010675445C86803240 @default.
• W2010675445 hasConceptScore W2010675445C94915269 @default.
• W2010675445 hasIssue "3-4" @default.
• W2010675445 hasLocation W20106754451 @default.
• W2010675445 hasLocation W20106754452 @default.
• W2010675445 hasOpenAccess W2010675445 @default.
• W2010675445 hasPrimaryLocation W20106754451 @default.
• W2010675445 hasRelatedWork W114491001 @default.
• W2010675445 hasRelatedWork W1986601832 @default.
• W2010675445 hasRelatedWork W2067416971 @default.
• W2010675445 hasRelatedWork W2142400691 @default.

• next