Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010678287> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2010678287 endingPage "490" @default.
- W2010678287 startingPage "487" @default.
- W2010678287 abstract "The addition of second trimester serum markers to maternal age increases the efficacy of screening for Down syndrome by maternal age alone. Among women aged 35 years or older, serum screening makes a large proportion of amniocentesis unnecessary. However, there are ethical and medicolegal concerns about serum screening in 'old' women, largely because some of the pregnancies affected by Down syndrome and other chromosomal abnormalities may not be detected. We investigated the acceptability of serum screening in women aged 35 years or older when it was offered as an alternative to prenatal cytogenetic diagnosis after detailed counselling. Women referred for prenatal diagnosis of Down syndrome because of advanced maternal age were given the options of cytogenetic diagnosis by chorionic villus sampling (CVS) or amniocentesis. As an alternative, they could choose to undergo second trimester serum human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) screening first before deciding on whether to undergo amniocentesis. Between January 1997 and October 1999, 3419 subjects were recruited. 1807 women (52. 9%) chose to undergo serum screening, 1516 women (44.3%) chose to have amniocentesis and 96 women chose to have CVS (2.8%). The proportion of women who chose serum screening rose steadily from 38. 8% in the year of 1997 to 63.4% in 1999. Significantly fewer Chinese women chose serum screening than non-Chinese. The decision as to whether to undergo an invasive diagnostic procedure or to be content with the relatively safer but less accurate screening test varies, being affected by the women's background and culture." @default.
- W2010678287 created "2016-06-24" @default.
- W2010678287 creator A5011905920 @default.
- W2010678287 creator A5012965312 @default.
- W2010678287 creator A5032296092 @default.
- W2010678287 creator A5034146928 @default.
- W2010678287 creator A5057999989 @default.
- W2010678287 creator A5075322875 @default.
- W2010678287 creator A5080980770 @default.
- W2010678287 date "2000-01-01" @default.
- W2010678287 modified "2023-10-03" @default.
- W2010678287 title "Acceptability of serum screening as an alternative to cytogenetic diagnosis of Down syndrome among women 35 years or older in Hong Kong" @default.
- W2010678287 cites W1909974778 @default.
- W2010678287 cites W1967882786 @default.
- W2010678287 cites W1973142697 @default.
- W2010678287 cites W1973775128 @default.
- W2010678287 cites W1975778088 @default.
- W2010678287 cites W1996337531 @default.
- W2010678287 cites W2010320636 @default.
- W2010678287 cites W2048629333 @default.
- W2010678287 cites W2076768832 @default.
- W2010678287 cites W2147820238 @default.
- W2010678287 cites W2157715053 @default.
- W2010678287 cites W2617785957 @default.
- W2010678287 doi "https://doi.org/10.1002/1097-0223(200006)20:6<487::aid-pd853>3.0.co;2-2" @default.
- W2010678287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10861714" @default.
- W2010678287 hasPublicationYear "2000" @default.
- W2010678287 type Work @default.
- W2010678287 sameAs 2010678287 @default.
- W2010678287 citedByCount "13" @default.
- W2010678287 countsByYear W20106782872012 @default.
- W2010678287 countsByYear W20106782872014 @default.
- W2010678287 countsByYear W20106782872015 @default.
- W2010678287 countsByYear W20106782872017 @default.
- W2010678287 countsByYear W20106782872018 @default.
- W2010678287 crossrefType "journal-article" @default.
- W2010678287 hasAuthorship W2010678287A5011905920 @default.
- W2010678287 hasAuthorship W2010678287A5012965312 @default.
- W2010678287 hasAuthorship W2010678287A5032296092 @default.
- W2010678287 hasAuthorship W2010678287A5034146928 @default.
- W2010678287 hasAuthorship W2010678287A5057999989 @default.
- W2010678287 hasAuthorship W2010678287A5075322875 @default.
- W2010678287 hasAuthorship W2010678287A5080980770 @default.
- W2010678287 hasConcept C118552586 @default.
- W2010678287 hasConcept C131872663 @default.
- W2010678287 hasConcept C172680121 @default.
- W2010678287 hasConcept C2776352029 @default.
- W2010678287 hasConcept C2776555163 @default.
- W2010678287 hasConcept C2777966818 @default.
- W2010678287 hasConcept C2778258057 @default.
- W2010678287 hasConcept C2779234561 @default.
- W2010678287 hasConcept C2779954681 @default.
- W2010678287 hasConcept C29456083 @default.
- W2010678287 hasConcept C54355233 @default.
- W2010678287 hasConcept C71924100 @default.
- W2010678287 hasConcept C86803240 @default.
- W2010678287 hasConceptScore W2010678287C118552586 @default.
- W2010678287 hasConceptScore W2010678287C131872663 @default.
- W2010678287 hasConceptScore W2010678287C172680121 @default.
- W2010678287 hasConceptScore W2010678287C2776352029 @default.
- W2010678287 hasConceptScore W2010678287C2776555163 @default.
- W2010678287 hasConceptScore W2010678287C2777966818 @default.
- W2010678287 hasConceptScore W2010678287C2778258057 @default.
- W2010678287 hasConceptScore W2010678287C2779234561 @default.
- W2010678287 hasConceptScore W2010678287C2779954681 @default.
- W2010678287 hasConceptScore W2010678287C29456083 @default.
- W2010678287 hasConceptScore W2010678287C54355233 @default.
- W2010678287 hasConceptScore W2010678287C71924100 @default.
- W2010678287 hasConceptScore W2010678287C86803240 @default.
- W2010678287 hasIssue "6" @default.
- W2010678287 hasLocation W20106782871 @default.
- W2010678287 hasLocation W20106782872 @default.
- W2010678287 hasOpenAccess W2010678287 @default.
- W2010678287 hasPrimaryLocation W20106782871 @default.
- W2010678287 hasRelatedWork W1978014180 @default.
- W2010678287 hasRelatedWork W2010598302 @default.
- W2010678287 hasRelatedWork W2049899708 @default.
- W2010678287 hasRelatedWork W2059257743 @default.
- W2010678287 hasRelatedWork W2066672287 @default.
- W2010678287 hasRelatedWork W2078626177 @default.
- W2010678287 hasRelatedWork W2127820612 @default.
- W2010678287 hasRelatedWork W2383181179 @default.
- W2010678287 hasRelatedWork W2408984006 @default.
- W2010678287 hasRelatedWork W4205864319 @default.
- W2010678287 hasVolume "20" @default.
- W2010678287 isParatext "false" @default.
- W2010678287 isRetracted "false" @default.
- W2010678287 magId "2010678287" @default.
- W2010678287 workType "article" @default.