FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010680324> ?p ?o ?g. }

• W2010680324 endingPage "e31862" @default.
• W2010680324 startingPage "e31862" @default.
• W2010680324 abstract "Mismatch repair-deficient colorectal cancers (CRC) display widespread instability at DNA microsatellite sequences (MSI). Although MSI has been reported to commonly occur at coding repeats, leading to alterations in the function of a number of genes encoding cancer-related proteins, nothing is known about the putative impact of this process on non-coding microRNAs. In miRbase V15, we identified very few human microRNA genes with mono- or di-nucleotide repeats (n = 27). A mutational analysis of these sequences in a large series of MSI CRC cell lines and primary tumors underscored instability in 15 of the 24 microRNA genes successfully studied at variable frequencies ranging from 2.5% to 100%. Following a maximum likelihood statistical method, microRNA genes were separated into two groups that differed significantly in their mutation frequencies and in their tendency to represent mutations that may or may not be under selective pressures during MSI tumoral progression. The first group included 21 genes that displayed no or few mutations in CRC. The second group contained three genes, i.e., hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent (≥80%) and sometimes bi-allelic mutations in MSI tumors. For the only one expressed in colonic tissues, hsa-mir-1303, no direct link was found between the presence or not of mono- or bi-allelic alterations and the levels of mature miR expression in MSI cell lines, as determined by sequencing and quantitative PCR respectively. Overall, our results provide evidence that DNA repeats contained in human miRNA genes are relatively rare and preserved from mutations due to MSI in MMR-deficient cancer cells. Functional studies are now required to conclude whether mutated miRNAs, and especially the miR-1303, might have a role in MSI tumorigenesis." @default.
• W2010680324 created "2016-06-24" @default.
• W2010680324 creator A5010902289 @default.
• W2010680324 creator A5014203330 @default.
• W2010680324 creator A5024775717 @default.
• W2010680324 creator A5038592146 @default.
• W2010680324 creator A5061045642 @default.
• W2010680324 creator A5075685329 @default.
• W2010680324 creator A5077121627 @default.
• W2010680324 creator A5081543867 @default.
• W2010680324 creator A5084448152 @default.
• W2010680324 date "2012-02-14" @default.
• W2010680324 modified "2023-10-18" @default.
• W2010680324 title "MiRNA Genes Constitute New Targets for Microsatellite Instability in Colorectal Cancer" @default.
• W2010680324 cites W1648301895 @default.
• W2010680324 cites W1968008181 @default.
• W2010680324 cites W1969853607 @default.
• W2010680324 cites W1971460830 @default.
• W2010680324 cites W1975437957 @default.
• W2010680324 cites W1980735015 @default.
• W2010680324 cites W1985974546 @default.
• W2010680324 cites W2012258341 @default.
• W2010680324 cites W2023858596 @default.
• W2010680324 cites W2040981801 @default.
• W2010680324 cites W2041146525 @default.
• W2010680324 cites W2044782990 @default.
• W2010680324 cites W2055193388 @default.
• W2010680324 cites W2058757079 @default.
• W2010680324 cites W2059357290 @default.
• W2010680324 cites W2063375027 @default.
• W2010680324 cites W2066213138 @default.
• W2010680324 cites W2070571588 @default.
• W2010680324 cites W2073491406 @default.
• W2010680324 cites W2094390470 @default.
• W2010680324 cites W2100092338 @default.
• W2010680324 cites W2102161750 @default.
• W2010680324 cites W2106018842 @default.
• W2010680324 cites W2110503511 @default.
• W2010680324 cites W2114499007 @default.
• W2010680324 cites W2145352784 @default.
• W2010680324 cites W2147366336 @default.
• W2010680324 cites W2154294588 @default.
• W2010680324 cites W2171393946 @default.
• W2010680324 doi "https://doi.org/10.1371/journal.pone.0031862" @default.
• W2010680324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3279428" @default.
• W2010680324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22348132" @default.
• W2010680324 hasPublicationYear "2012" @default.
• W2010680324 type Work @default.
• W2010680324 sameAs 2010680324 @default.
• W2010680324 citedByCount "37" @default.
• W2010680324 countsByYear W20106803242012 @default.
• W2010680324 countsByYear W20106803242013 @default.
• W2010680324 countsByYear W20106803242014 @default.
• W2010680324 countsByYear W20106803242015 @default.
• W2010680324 countsByYear W20106803242016 @default.
• W2010680324 countsByYear W20106803242018 @default.
• W2010680324 countsByYear W20106803242019 @default.
• W2010680324 countsByYear W20106803242020 @default.
• W2010680324 countsByYear W20106803242021 @default.
• W2010680324 countsByYear W20106803242022 @default.
• W2010680324 countsByYear W20106803242023 @default.
• W2010680324 crossrefType "journal-article" @default.
• W2010680324 hasAuthorship W2010680324A5010902289 @default.
• W2010680324 hasAuthorship W2010680324A5014203330 @default.
• W2010680324 hasAuthorship W2010680324A5024775717 @default.
• W2010680324 hasAuthorship W2010680324A5038592146 @default.
• W2010680324 hasAuthorship W2010680324A5061045642 @default.
• W2010680324 hasAuthorship W2010680324A5075685329 @default.
• W2010680324 hasAuthorship W2010680324A5077121627 @default.
• W2010680324 hasAuthorship W2010680324A5081543867 @default.
• W2010680324 hasAuthorship W2010680324A5084448152 @default.
• W2010680324 hasBestOaLocation W20106803241 @default.
• W2010680324 hasConcept C104317684 @default.
• W2010680324 hasConcept C134935766 @default.
• W2010680324 hasConcept C145059251 @default.
• W2010680324 hasConcept C180754005 @default.
• W2010680324 hasConcept C2779767149 @default.
• W2010680324 hasConcept C49305753 @default.
• W2010680324 hasConcept C501734568 @default.
• W2010680324 hasConcept C54355233 @default.
• W2010680324 hasConcept C60748783 @default.
• W2010680324 hasConcept C61320498 @default.
• W2010680324 hasConcept C86803240 @default.
• W2010680324 hasConcept C91779695 @default.
• W2010680324 hasConceptScore W2010680324C104317684 @default.
• W2010680324 hasConceptScore W2010680324C134935766 @default.
• W2010680324 hasConceptScore W2010680324C145059251 @default.
• W2010680324 hasConceptScore W2010680324C180754005 @default.
• W2010680324 hasConceptScore W2010680324C2779767149 @default.
• W2010680324 hasConceptScore W2010680324C49305753 @default.
• W2010680324 hasConceptScore W2010680324C501734568 @default.
• W2010680324 hasConceptScore W2010680324C54355233 @default.
• W2010680324 hasConceptScore W2010680324C60748783 @default.
• W2010680324 hasConceptScore W2010680324C61320498 @default.
• W2010680324 hasConceptScore W2010680324C86803240 @default.
• W2010680324 hasConceptScore W2010680324C91779695 @default.
• W2010680324 hasIssue "2" @default.
• W2010680324 hasLocation W20106803241 @default.

• next