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• W2010682202 abstract "Small aquarium fishes become increasingly important in the study of normal vertebrate development and disease. Differential DNA methylation might play a role in these processes. In the teleost Xiphophorus, a well-established animal model for melanoma formation, tumour-specific hypomethylation of the melanoma-inducing gene ONC-Xmrk has been observed. We have isolated a cDNA for the DNA-(cytosine-5)-methyltransferase XDNMT-1 from this organism, which encodes the first full-length protein from a fish species. Linkage analysis showed that Xdnmt-1 is different from the Xiphophorus tumour suppressor R, which is involved in the transcriptional repression of the ONC-Xmrk melanoma oncogene in healthy fish. As methylation has been implicated in the regulation of ONC-Xmrk expression, XDNMT-1 might play a role by acting up- or downstream of R. Expression analysis demonstrated that the Xdnmt-1 transcript is present in all adult tissues and cell lines tested. However, developing embryos show a spatially and temporally regulated expression pattern suggesting that the enzyme might play a role during development in fish." @default.
• W2010682202 created "2016-06-24" @default.
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• W2010682202 date "2000-05-01" @default.
• W2010682202 modified "2023-10-16" @default.
• W2010682202 title "Primary structure and expression of the Xiphophorus DNA-(cytosine-5)-methyltransferase XDNMT-1" @default.
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• W2010682202 doi "https://doi.org/10.1016/s0378-1119(00)00155-4" @default.
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