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• W2010682265 abstract "A series of mutations was targeted at the methionine residue, Met471, coordinating the CuM site of tyramine β-monooxygenase (TβM). The methionine ligand at CuM is believed to be key to dioxygen activation and the hydroxylation chemistry of the copper monooxygenases. The reactivity and copper binding properties of three TβM mutants, Met471Asp, Met471Cys, and Met471His, were examined. All three mutants show similar metal binding affinities to wild type TβM in the oxidized enzyme forms. EPR spectroscopy suggests that the CuII coordination geometry is identical to that of the WT enzyme. However, substrate hydroxylation was observed for the reaction of tyramine solely with Met471Cys TβM. Met471Cys TβM provides the first example of an active mutant directed at the CuM site of this class of hydroxylases. The reactivity and altered kinetics of the Met471Cys mutant further highlight the central role of the methionine residue in the enzyme mechanism. The sole ability of the cysteine residue to support activity among the series of alternate amino acids investigated is relevant to theoretical and biomimetic investigations of dioxygen activation at mononuclear copper centers." @default.
• W2010682265 created "2016-06-24" @default.
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• W2010682265 date "2008-08-19" @default.
• W2010682265 modified "2023-09-27" @default.
• W2010682265 title "Hydroxylase Activity of Met471Cys Tyramine β-Monooxygenase" @default.
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• W2010682265 doi "https://doi.org/10.1021/ja800408h" @default.
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