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• W2010683612 startingPage "11352" @default.
• W2010683612 abstract "A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer simulations are carried out to demonstrate how the various subsystems operate to delay or arrest cell cycle progression. The detailed model could be used to explain various experiments relevant to G2DDC reported recently, including the nuclear export of 14-3-3-bound Cdc25, the down-regulation of cyclin B1 expression by p53, the effect of Chk1 and p53 on Cdc25 levels, and Wee1 degradation. It also is shown that, under certain conditions, p53 is necessary to sustain a G(2) arrest." @default.
• W2010683612 created "2016-06-24" @default.
• W2010683612 creator A5075726143 @default.
• W2010683612 date "1999-09-28" @default.
• W2010683612 modified "2023-09-24" @default.
• W2010683612 title "A quantitative analysis of the kinetics of the G ₂ DNA damage checkpoint system" @default.
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• W2010683612 doi "https://doi.org/10.1073/pnas.96.20.11352" @default.
• W2010683612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18037" @default.
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