FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010689021> ?p ?o ?g. }

• W2010689021 endingPage "49" @default.
• W2010689021 startingPage "40" @default.
• W2010689021 abstract "Objective To examine the efficacy and safety of recombinant human growth hormone (rhGH) therapy in congestive heart failure (CHF) by conducting a meta-analysis of clinical studies. Methods We searched 3 literature databases (MEDLINE, EMBASE, and the Cochrane Register) for clinical studies of rhGH therapy in CHF due to systolic dysfunction and conducted a meta-analysis. Results Therapy with rhGH appears to have beneficial clinical effects (weighted mean difference [95% confidence interval]) in CHF including improved exercise duration (1.9 min [1.1-2.7]), maximum oxygen consumption (2.1 mL·kg–1·min–1 [1.2-3.0]), and New York Heart Association class (–0.9 [–1.5 to –0.3]). There were salutary hemodynamic effects of rhGH therapy, including increased cardiac output (0.4 L·min–1 [0.1-0.6]) and decreased systemic vascular resistance (–177 dyn·s·cm–5 [–279 to –74]). Among rhGH–treated patients, left ventricular (LV) ejection fraction improved (4.3% [2.2-6.4]). Despite increases in LV mass and wall thickness, there were no adverse effects on diastolic function. Subgroup analyses suggest that study design and treatment duration may influence some of the treatment effects. Most of the beneficial effects were driven by either uncontrolled or longer duration studies. Administration of rhGH therapy slightly increased the risk for ventricular arrhythmia; however, this finding was driven by a single small study. Conclusion rhGH therapy may have beneficial cardiovascular effects in CHF caused by LV systolic dysfunction. The possibility of proarrhythmia associated with rhGH therapy requires further study. Larger randomized trials with longer treatment duration are needed to fully elucidate the efficacy and safety of rhGH therapy in this patient population. (Endocr Pract. 2008;14:40-49)" @default.
• W2010689021 created "2016-06-24" @default.
• W2010689021 creator A5046245100 @default.
• W2010689021 creator A5063368197 @default.
• W2010689021 date "2008-01-01" @default.
• W2010689021 modified "2023-09-27" @default.
• W2010689021 title "Growth Hormone Therapy in Congestive Heart Failure Due to Left Ventricular Systolic Dysfunction: a Meta-Analysis" @default.
• W2010689021 cites W1965155710 @default.
• W2010689021 cites W1978311945 @default.
• W2010689021 cites W1983964548 @default.
• W2010689021 cites W1984590777 @default.
• W2010689021 cites W1986001051 @default.
• W2010689021 cites W1996040533 @default.
• W2010689021 cites W1996122438 @default.
• W2010689021 cites W2014494460 @default.
• W2010689021 cites W2018898870 @default.
• W2010689021 cites W2021693335 @default.
• W2010689021 cites W2023189607 @default.
• W2010689021 cites W2026607523 @default.
• W2010689021 cites W2026782802 @default.
• W2010689021 cites W2031739105 @default.
• W2010689021 cites W2031752381 @default.
• W2010689021 cites W2035374964 @default.
• W2010689021 cites W2038105345 @default.
• W2010689021 cites W2042088579 @default.
• W2010689021 cites W2054323684 @default.
• W2010689021 cites W2059044848 @default.
• W2010689021 cites W2068918386 @default.
• W2010689021 cites W2069457676 @default.
• W2010689021 cites W2077516614 @default.
• W2010689021 cites W2080259446 @default.
• W2010689021 cites W2083532784 @default.
• W2010689021 cites W2087528154 @default.
• W2010689021 cites W2092664851 @default.
• W2010689021 cites W2099036797 @default.
• W2010689021 cites W2102751037 @default.
• W2010689021 cites W2105144228 @default.
• W2010689021 cites W2107328434 @default.
• W2010689021 cites W2108122320 @default.
• W2010689021 cites W2119770786 @default.
• W2010689021 cites W2125417265 @default.
• W2010689021 cites W2125511797 @default.
• W2010689021 cites W2126572860 @default.
• W2010689021 cites W2130816652 @default.
• W2010689021 cites W2132001222 @default.
• W2010689021 cites W2132587726 @default.
• W2010689021 cites W2136566853 @default.
• W2010689021 cites W2146804166 @default.
• W2010689021 cites W2155531603 @default.
• W2010689021 cites W2171527314 @default.
• W2010689021 cites W2336383135 @default.
• W2010689021 cites W2409888680 @default.
• W2010689021 doi "https://doi.org/10.4158/ep.14.1.40" @default.
• W2010689021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18238740" @default.
• W2010689021 hasPublicationYear "2008" @default.
• W2010689021 type Work @default.
• W2010689021 sameAs 2010689021 @default.
• W2010689021 citedByCount "18" @default.
• W2010689021 countsByYear W20106890212014 @default.
• W2010689021 countsByYear W20106890212018 @default.
• W2010689021 countsByYear W20106890212019 @default.
• W2010689021 countsByYear W20106890212020 @default.
• W2010689021 countsByYear W20106890212022 @default.
• W2010689021 crossrefType "journal-article" @default.
• W2010689021 hasAuthorship W2010689021A5046245100 @default.
• W2010689021 hasAuthorship W2010689021A5063368197 @default.
• W2010689021 hasConcept C126322002 @default.
• W2010689021 hasConcept C164705383 @default.
• W2010689021 hasConcept C178853913 @default.
• W2010689021 hasConcept C197934379 @default.
• W2010689021 hasConcept C2778198053 @default.
• W2010689021 hasConcept C57900726 @default.
• W2010689021 hasConcept C58245268 @default.
• W2010689021 hasConcept C71924100 @default.
• W2010689021 hasConcept C78085059 @default.
• W2010689021 hasConcept C84393581 @default.
• W2010689021 hasConcept C95190672 @default.
• W2010689021 hasConceptScore W2010689021C126322002 @default.
• W2010689021 hasConceptScore W2010689021C164705383 @default.
• W2010689021 hasConceptScore W2010689021C178853913 @default.
• W2010689021 hasConceptScore W2010689021C197934379 @default.
• W2010689021 hasConceptScore W2010689021C2778198053 @default.
• W2010689021 hasConceptScore W2010689021C57900726 @default.
• W2010689021 hasConceptScore W2010689021C58245268 @default.
• W2010689021 hasConceptScore W2010689021C71924100 @default.
• W2010689021 hasConceptScore W2010689021C78085059 @default.
• W2010689021 hasConceptScore W2010689021C84393581 @default.
• W2010689021 hasConceptScore W2010689021C95190672 @default.
• W2010689021 hasIssue "1" @default.
• W2010689021 hasLocation W20106890211 @default.
• W2010689021 hasOpenAccess W2010689021 @default.
• W2010689021 hasPrimaryLocation W20106890211 @default.
• W2010689021 hasRelatedWork W1949634191 @default.
• W2010689021 hasRelatedWork W1964205598 @default.
• W2010689021 hasRelatedWork W2051712573 @default.
• W2010689021 hasRelatedWork W2077083067 @default.
• W2010689021 hasRelatedWork W2091139515 @default.
• W2010689021 hasRelatedWork W2355594703 @default.

• next