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- W2010689482 abstract "It is unclear whether or not the CSF cytokine profiles in viral meningitis differ with the kind of causative virus. We measured the concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), IL-4, IL-6, and IL-10 in CSF during the acute stage in 15 children with mumps meningitis (MM), and 34 with echovirus type 30 meningitis (EM). The CSF IFN-γ, IL-2, IL-6, and IL-10 levels were elevated in MM, and the CSF IFN-γ, IL-2, and IL-6 levels were elevated in EM. The CSF IFN-γ, IL-2, and IL-10 levels in MM were significantly higher than those in EM (p < 0.0001, p < 0.0001, and p < 0.0001, respectively). The CSF IL-6 levels in EM were significantly higher than those in MM (p = 0.0255). The CSF TNF-α and IL-4 levels were not elevated in MM or EM. In MM, the IL-6 level was correlated with the IL-2 and IL-10 levels in CSF (p = 0.0347 and p = 0.0120, respectively). In EM, the IFN-γ level was correlated with the IL-10 level in CSF (p = 0.0002). CSF cytokine profiles in MM were different from those in EM. Therefore, it is likely that the pathogenesis of MM is different from that of EM." @default.
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- W2010689482 date "2005-06-01" @default.
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- W2010689482 title "Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: Comparison with echovirus type 30 meningitis" @default.
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- W2010689482 doi "https://doi.org/10.1016/j.cyto.2005.01.022" @default.
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