FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010702016> ?p ?o ?g. }

• W2010702016 endingPage "231" @default.
• W2010702016 startingPage "224" @default.
• W2010702016 abstract "It is widely accepted that the pathophysiological mechanism of severe acute pancreatitis (SAP) is characterized by the systemic inflammatory response, which eventually causes systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and even death. Heme oxygenase (HO)-1 has been proved to exert anti-inflammatory benefit in a variety of inflammatory diseases, and a variety of methods by which HO-1 overexpression can be induced have been reported. In this study, we hypothesized that transfer of HO-1 gene by adenoviral vector could inhibit the systemic inflammation and the development of MODS. Sprague-Dawley (SD) rats were used as subjects in this study. Each was made into SAP model by retrograded injection through pancreatic duct with 5% sodium taurocholate (0.1 mL/100 g). Normal saline (1 mL/animal) or adenoviral HO-1 gene (Adv-HO-1, 2.0 × 10 PFU/mL/animal) or adenoviral empty vectors (Adv-0, 2.0 × 10 PFU/mL/animal) were injected intraperitoneally. HO-1 expression in serum and tissues including pancreas, liver and kidney was measured and observed to be upregulated in the rats treated with Adv-HO-1. The administration of Adv-HO-1 also inhibited the expression of tumor necrosis factor (TNF)-α and boosted the expression of interleukin-10 (IL-10). The decreasing serum concentration of ALT, AST, BUN and CREA, the amelioration of histopathologic damage in pancreas, liver and kidney tissues, the improvement of survival rate were all observed in rats treated with Adv-HO-1 comparing to others. As a result, this study showed that Adv-HO-1 could exert protective effect including anti-inflammation and organ protection through enhancing the expression of HO-1 in SAP." @default.
• W2010702016 created "2016-06-24" @default.
• W2010702016 creator A5003641601 @default.
• W2010702016 creator A5034083344 @default.
• W2010702016 creator A5034458392 @default.
• W2010702016 creator A5087690220 @default.
• W2010702016 creator A5088965321 @default.
• W2010702016 date "2014-09-01" @default.
• W2010702016 modified "2023-09-23" @default.
• W2010702016 title "Protective Effect of Adenoviral Transfer of Heme Oxygenase-1 Gene on Rats With Severe Acute Pancreatitis" @default.
• W2010702016 cites W1964799256 @default.
• W2010702016 cites W1973269177 @default.
• W2010702016 cites W1977094630 @default.
• W2010702016 cites W1977445279 @default.
• W2010702016 cites W1987224119 @default.
• W2010702016 cites W1990488806 @default.
• W2010702016 cites W1990566288 @default.
• W2010702016 cites W1992801219 @default.
• W2010702016 cites W1993226662 @default.
• W2010702016 cites W1993401516 @default.
• W2010702016 cites W1996780964 @default.
• W2010702016 cites W1999765176 @default.
• W2010702016 cites W2001677608 @default.
• W2010702016 cites W2010929029 @default.
• W2010702016 cites W2016861137 @default.
• W2010702016 cites W2021650047 @default.
• W2010702016 cites W2032773998 @default.
• W2010702016 cites W2034276841 @default.
• W2010702016 cites W2045427406 @default.
• W2010702016 cites W2060195530 @default.
• W2010702016 cites W2063513460 @default.
• W2010702016 cites W2071707068 @default.
• W2010702016 cites W2073525424 @default.
• W2010702016 cites W2086603776 @default.
• W2010702016 cites W2090143261 @default.
• W2010702016 cites W2094835188 @default.
• W2010702016 cites W2094847593 @default.
• W2010702016 cites W2095128491 @default.
• W2010702016 cites W2109299562 @default.
• W2010702016 cites W2130621723 @default.
• W2010702016 cites W2137172559 @default.
• W2010702016 cites W2145828433 @default.
• W2010702016 cites W2151134019 @default.
• W2010702016 cites W2160334169 @default.
• W2010702016 cites W2163792649 @default.
• W2010702016 cites W2170191859 @default.
• W2010702016 cites W2416139742 @default.
• W2010702016 doi "https://doi.org/10.1097/maj.0000000000000225" @default.
• W2010702016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24694788" @default.
• W2010702016 hasPublicationYear "2014" @default.
• W2010702016 type Work @default.
• W2010702016 sameAs 2010702016 @default.
• W2010702016 citedByCount "12" @default.
• W2010702016 countsByYear W20107020162014 @default.
• W2010702016 countsByYear W20107020162015 @default.
• W2010702016 countsByYear W20107020162016 @default.
• W2010702016 countsByYear W20107020162017 @default.
• W2010702016 countsByYear W20107020162018 @default.
• W2010702016 countsByYear W20107020162019 @default.
• W2010702016 countsByYear W20107020162020 @default.
• W2010702016 countsByYear W20107020162023 @default.
• W2010702016 crossrefType "journal-article" @default.
• W2010702016 hasAuthorship W2010702016A5003641601 @default.
• W2010702016 hasAuthorship W2010702016A5034083344 @default.
• W2010702016 hasAuthorship W2010702016A5034458392 @default.
• W2010702016 hasAuthorship W2010702016A5087690220 @default.
• W2010702016 hasAuthorship W2010702016A5088965321 @default.
• W2010702016 hasConcept C10162356 @default.
• W2010702016 hasConcept C126322002 @default.
• W2010702016 hasConcept C17991360 @default.
• W2010702016 hasConcept C181199279 @default.
• W2010702016 hasConcept C203014093 @default.
• W2010702016 hasConcept C2775967933 @default.
• W2010702016 hasConcept C2776217839 @default.
• W2010702016 hasConcept C2776252253 @default.
• W2010702016 hasConcept C2776670229 @default.
• W2010702016 hasConcept C2776914184 @default.
• W2010702016 hasConcept C2778384902 @default.
• W2010702016 hasConcept C2778764654 @default.
• W2010702016 hasConcept C2779219270 @default.
• W2010702016 hasConcept C2780091579 @default.
• W2010702016 hasConcept C2780835948 @default.
• W2010702016 hasConcept C2781090800 @default.
• W2010702016 hasConcept C55493867 @default.
• W2010702016 hasConcept C71924100 @default.
• W2010702016 hasConcept C86803240 @default.
• W2010702016 hasConceptScore W2010702016C10162356 @default.
• W2010702016 hasConceptScore W2010702016C126322002 @default.
• W2010702016 hasConceptScore W2010702016C17991360 @default.
• W2010702016 hasConceptScore W2010702016C181199279 @default.
• W2010702016 hasConceptScore W2010702016C203014093 @default.
• W2010702016 hasConceptScore W2010702016C2775967933 @default.
• W2010702016 hasConceptScore W2010702016C2776217839 @default.
• W2010702016 hasConceptScore W2010702016C2776252253 @default.
• W2010702016 hasConceptScore W2010702016C2776670229 @default.
• W2010702016 hasConceptScore W2010702016C2776914184 @default.
• W2010702016 hasConceptScore W2010702016C2778384902 @default.
• W2010702016 hasConceptScore W2010702016C2778764654 @default.

• next