FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010702833> ?p ?o ?g. }

• W2010702833 endingPage "126" @default.
• W2010702833 startingPage "119" @default.
• W2010702833 abstract "Azoxymethane (AOM) is a methylating agent capable of inducing mutations in DNA by forming adducts with DNA bases. It has been used to understand the mechanisms involved in colon carcinogenesis. Of the adducts formed in response to AOM, O6-methyl-2′-deoxy-guanosine (O6-mdGua) is the most mutagenic. Based on studies in rodents of the abundance and persistence of DNA adducts in various tissues after treatment with alkylating agents, previous results suggest, as a generalization, that the longer O6-mdGua adducts remain unrepaired in the cells of a tissue, the greater the risk for tumorigenesis. To test this hypothesis, we have built on these studies, expanding the number of tissues in which O6-mdGua abundance and persistence were examined and correlating these data with tumour distribution and abundance in rats maintained for 26 weeks after the treatment with AOM. Our study revealed firstly the existence of groups of tissues that developed relatively large amounts (proximal and distal colon, proximal small intestine (SI), liver and kidney) and relatively low levels (stomach, distal SI, bladder, spleen, blood and lung) of O6-mdGua after AOM exposure. Secondly, while all tissues showed an increase in adduct levels at 6 h after mutagen treatment and most showed a significant drop in adduct levels between 6 h and 48 h (stomach, proximal and distal SI, liver, spleen, blood and lung), one group of tissues displayed O6-mdGua levels that did not decrease at 48 h (proximal and distal colon, kidney and bladder). Predictably, the colon displayed tumours 26 weeks after treatment. Interestingly, however, the proximal SI also displayed significant tumour formation at that time. Our findings demonstrate (1) a direct association between exposure to O6-mdGua and tumours of the distal colon and (2) a dissociation of the relationship between adduct clearance and tumorigenesis in the SI. This diversity of response in the gastrointestinal tract warrants further analysis." @default.
• W2010702833 created "2016-06-24" @default.
• W2010702833 creator A5007472322 @default.
• W2010702833 creator A5029122725 @default.
• W2010702833 creator A5031766635 @default.
• W2010702833 creator A5048068162 @default.
• W2010702833 creator A5070240930 @default.
• W2010702833 creator A5076298077 @default.
• W2010702833 creator A5082904583 @default.
• W2010702833 date "2011-04-01" @default.
• W2010702833 modified "2023-10-16" @default.
• W2010702833 title "Is the tissue persistence of O6-methyl-2′-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?" @default.
• W2010702833 cites W1831301545 @default.
• W2010702833 cites W1970159075 @default.
• W2010702833 cites W1971344938 @default.
• W2010702833 cites W1971851714 @default.
• W2010702833 cites W1973243594 @default.
• W2010702833 cites W1982587363 @default.
• W2010702833 cites W1989616297 @default.
• W2010702833 cites W2003396737 @default.
• W2010702833 cites W2007059663 @default.
• W2010702833 cites W2008591865 @default.
• W2010702833 cites W2013402621 @default.
• W2010702833 cites W2016789358 @default.
• W2010702833 cites W2017985800 @default.
• W2010702833 cites W2026195203 @default.
• W2010702833 cites W2028834400 @default.
• W2010702833 cites W2033776031 @default.
• W2010702833 cites W2059804014 @default.
• W2010702833 cites W2060423073 @default.
• W2010702833 cites W2064414056 @default.
• W2010702833 cites W2085039518 @default.
• W2010702833 cites W2096812094 @default.
• W2010702833 cites W2097111597 @default.
• W2010702833 cites W2100097387 @default.
• W2010702833 cites W2105860096 @default.
• W2010702833 cites W2109570760 @default.
• W2010702833 cites W2116103702 @default.
• W2010702833 cites W2117009362 @default.
• W2010702833 cites W2117222904 @default.
• W2010702833 cites W2125628175 @default.
• W2010702833 cites W2134090171 @default.
• W2010702833 cites W2134891788 @default.
• W2010702833 cites W2139437532 @default.
• W2010702833 cites W2142118171 @default.
• W2010702833 cites W2146448202 @default.
• W2010702833 cites W2179627804 @default.
• W2010702833 cites W2188679378 @default.
• W2010702833 cites W2271855069 @default.
• W2010702833 cites W2286134743 @default.
• W2010702833 doi "https://doi.org/10.1016/j.mrgentox.2010.12.016" @default.
• W2010702833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21295156" @default.
• W2010702833 hasPublicationYear "2011" @default.
• W2010702833 type Work @default.
• W2010702833 sameAs 2010702833 @default.
• W2010702833 citedByCount "10" @default.
• W2010702833 countsByYear W20107028332012 @default.
• W2010702833 countsByYear W20107028332013 @default.
• W2010702833 countsByYear W20107028332014 @default.
• W2010702833 countsByYear W20107028332016 @default.
• W2010702833 countsByYear W20107028332017 @default.
• W2010702833 countsByYear W20107028332022 @default.
• W2010702833 crossrefType "journal-article" @default.
• W2010702833 hasAuthorship W2010702833A5007472322 @default.
• W2010702833 hasAuthorship W2010702833A5029122725 @default.
• W2010702833 hasAuthorship W2010702833A5031766635 @default.
• W2010702833 hasAuthorship W2010702833A5048068162 @default.
• W2010702833 hasAuthorship W2010702833A5070240930 @default.
• W2010702833 hasAuthorship W2010702833A5076298077 @default.
• W2010702833 hasAuthorship W2010702833A5082904583 @default.
• W2010702833 hasConcept C104317684 @default.
• W2010702833 hasConcept C126322002 @default.
• W2010702833 hasConcept C134018914 @default.
• W2010702833 hasConcept C142724271 @default.
• W2010702833 hasConcept C185592680 @default.
• W2010702833 hasConcept C203014093 @default.
• W2010702833 hasConcept C2776639595 @default.
• W2010702833 hasConcept C2777714996 @default.
• W2010702833 hasConcept C2778452354 @default.
• W2010702833 hasConcept C2779422922 @default.
• W2010702833 hasConcept C2780091579 @default.
• W2010702833 hasConcept C2780441211 @default.
• W2010702833 hasConcept C2780512811 @default.
• W2010702833 hasConcept C2780931953 @default.
• W2010702833 hasConcept C2781247443 @default.
• W2010702833 hasConcept C552990157 @default.
• W2010702833 hasConcept C55493867 @default.
• W2010702833 hasConcept C555283112 @default.
• W2010702833 hasConcept C71924100 @default.
• W2010702833 hasConcept C86803240 @default.
• W2010702833 hasConceptScore W2010702833C104317684 @default.
• W2010702833 hasConceptScore W2010702833C126322002 @default.
• W2010702833 hasConceptScore W2010702833C134018914 @default.
• W2010702833 hasConceptScore W2010702833C142724271 @default.
• W2010702833 hasConceptScore W2010702833C185592680 @default.
• W2010702833 hasConceptScore W2010702833C203014093 @default.
• W2010702833 hasConceptScore W2010702833C2776639595 @default.
• W2010702833 hasConceptScore W2010702833C2777714996 @default.

• next