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- W2010707654 abstract "Novel nucleoside analogues of both D and L enantiomeric series were prepared by coupling reaction between a 2',3'-dideoxy-3'-modified furanose moiety and four different nucleobases. Though in all cases anomeric mixtures of nucleosides were obtained, the presence of the sterically bulky 3'-tris(methylthio)methyl group allowed a good stereoselectivity level. All the compounds of both enantiomeric series showed high IC(50) values as HSV-1 TK inhibitors and scarce ability to be phosphorylated by HSV-1 TK. In order to overcome possible problems related to the first phosphorylation step and to facilitate the penetration of the molecule through the cellular membrane, a monophosphate prodrug containing a long lipophilic chain was synthesized. No appreciable antiviral activity was exhibited by this molecule." @default.
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- W2010707654 date "2003-02-01" @default.
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- W2010707654 title "Research on l-Nucleosides. synthesis and biological evaluation of a series of l- and d-2′,3′-Dideoxy-3′-[tris(methylthio)methyl]-β-pentofuranosyl nucleosides" @default.
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- W2010707654 doi "https://doi.org/10.1016/s0968-0896(02)00460-1" @default.
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