FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010709196> ?p ?o ?g. }

• W2010709196 endingPage "394" @default.
• W2010709196 startingPage "387" @default.
• W2010709196 abstract "Although PI3K/Akt signaling that regulates neuronal survival has been implicated in the deleterious effects of ethanol on the central nervous system, underlying molecular mechanisms have not been fully elucidated. Akt-membrane interaction is a prerequisite step for Akt activation since it induces interdomain conformational changes to an open conformer that allows Akt phosphorylation by upstream kinases. In this study, we investigated the effect of ethanol on Akt activation by quantitatively probing Akt conformation using chemical cross-linking, (18)O labeling and mass spectrometry. We found that ethanol at pharmacologically relevant concentrations (20 or 170 mM) directly interacts with Akt and alters the local pleckstrin homology domain configuration near the PIP(3)-binding site. We also found that ethanol significantly impairs subsequent membrane-induced interdomain conformational changes needed for Akt activation. The observed alteration of Akt conformation caused by ethanol during the activation sequence provides a new molecular basis for the effects of ethanol on Akt signaling. The in vitro conformation-based approach employed in this study should also be useful in probing the molecular mechanisms for the action of ethanol or drugs on other signaling proteins, particularly for those undergoing dramatic conformational change during activation processes such as members of AGC kinase super family." @default.
• W2010709196 created "2016-06-24" @default.
• W2010709196 creator A5002218939 @default.
• W2010709196 creator A5075697261 @default.
• W2010709196 date "2011-12-07" @default.
• W2010709196 modified "2023-09-27" @default.
• W2010709196 title "Effects of Ethanol on Conformational Changes of Akt Studied by Chemical Cross-Linking, Mass Spectrometry, and ¹⁸O Labeling" @default.
• W2010709196 cites W1908445283 @default.
• W2010709196 cites W1967235964 @default.
• W2010709196 cites W1969134590 @default.
• W2010709196 cites W1970548320 @default.
• W2010709196 cites W1973837499 @default.
• W2010709196 cites W1975024278 @default.
• W2010709196 cites W1986228306 @default.
• W2010709196 cites W1987012315 @default.
• W2010709196 cites W1991860629 @default.
• W2010709196 cites W2004078164 @default.
• W2010709196 cites W2006419756 @default.
• W2010709196 cites W2018023891 @default.
• W2010709196 cites W2020931266 @default.
• W2010709196 cites W2024306318 @default.
• W2010709196 cites W2027731629 @default.
• W2010709196 cites W2047213097 @default.
• W2010709196 cites W2052709482 @default.
• W2010709196 cites W2056147301 @default.
• W2010709196 cites W2058523223 @default.
• W2010709196 cites W2064242629 @default.
• W2010709196 cites W2071694094 @default.
• W2010709196 cites W2077225758 @default.
• W2010709196 cites W2085316562 @default.
• W2010709196 cites W2097767970 @default.
• W2010709196 cites W2100880237 @default.
• W2010709196 cites W2101859467 @default.
• W2010709196 cites W2103263638 @default.
• W2010709196 cites W2111930403 @default.
• W2010709196 cites W2122340615 @default.
• W2010709196 cites W2126404692 @default.
• W2010709196 cites W2137035181 @default.
• W2010709196 cites W2138165144 @default.
• W2010709196 cites W2139804583 @default.
• W2010709196 cites W2150454530 @default.
• W2010709196 cites W2152171079 @default.
• W2010709196 cites W2162665706 @default.
• W2010709196 cites W2168337851 @default.
• W2010709196 doi "https://doi.org/10.1021/cb2003237" @default.
• W2010709196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3475205" @default.
• W2010709196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22129086" @default.
• W2010709196 hasPublicationYear "2011" @default.
• W2010709196 type Work @default.
• W2010709196 sameAs 2010709196 @default.
• W2010709196 citedByCount "9" @default.
• W2010709196 countsByYear W20107091962013 @default.
• W2010709196 countsByYear W20107091962014 @default.
• W2010709196 countsByYear W20107091962015 @default.
• W2010709196 countsByYear W20107091962016 @default.
• W2010709196 countsByYear W20107091962017 @default.
• W2010709196 countsByYear W20107091962022 @default.
• W2010709196 crossrefType "journal-article" @default.
• W2010709196 hasAuthorship W2010709196A5002218939 @default.
• W2010709196 hasAuthorship W2010709196A5075697261 @default.
• W2010709196 hasBestOaLocation W20107091962 @default.
• W2010709196 hasConcept C11960822 @default.
• W2010709196 hasConcept C12554922 @default.
• W2010709196 hasConcept C185592680 @default.
• W2010709196 hasConcept C2780161600 @default.
• W2010709196 hasConcept C49658373 @default.
• W2010709196 hasConcept C55493867 @default.
• W2010709196 hasConcept C62478195 @default.
• W2010709196 hasConcept C75217442 @default.
• W2010709196 hasConcept C86554907 @default.
• W2010709196 hasConcept C86803240 @default.
• W2010709196 hasConcept C95444343 @default.
• W2010709196 hasConceptScore W2010709196C11960822 @default.
• W2010709196 hasConceptScore W2010709196C12554922 @default.
• W2010709196 hasConceptScore W2010709196C185592680 @default.
• W2010709196 hasConceptScore W2010709196C2780161600 @default.
• W2010709196 hasConceptScore W2010709196C49658373 @default.
• W2010709196 hasConceptScore W2010709196C55493867 @default.
• W2010709196 hasConceptScore W2010709196C62478195 @default.
• W2010709196 hasConceptScore W2010709196C75217442 @default.
• W2010709196 hasConceptScore W2010709196C86554907 @default.
• W2010709196 hasConceptScore W2010709196C86803240 @default.
• W2010709196 hasConceptScore W2010709196C95444343 @default.
• W2010709196 hasIssue "2" @default.
• W2010709196 hasLocation W20107091961 @default.
• W2010709196 hasLocation W20107091962 @default.
• W2010709196 hasLocation W20107091963 @default.
• W2010709196 hasLocation W20107091964 @default.
• W2010709196 hasOpenAccess W2010709196 @default.
• W2010709196 hasPrimaryLocation W20107091961 @default.
• W2010709196 hasRelatedWork W1988602328 @default.
• W2010709196 hasRelatedWork W1996193561 @default.
• W2010709196 hasRelatedWork W2011860226 @default.
• W2010709196 hasRelatedWork W2026199302 @default.
• W2010709196 hasRelatedWork W2037154041 @default.
• W2010709196 hasRelatedWork W2108863061 @default.
• W2010709196 hasRelatedWork W2168778208 @default.
• W2010709196 hasRelatedWork W2328433417 @default.

• next