FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010713573> ?p ?o ?g. }

• W2010713573 endingPage "331" @default.
• W2010713573 startingPage "321" @default.
• W2010713573 abstract "Abstract: Crohn's disease (CD), a chronic inflammatory disease of the intestinal mucosa is usually located in the small intestine (ileum) and or in the colon. Ileal CD has been linked to a mutation in the NOD2 gene, a bacterial recognition protein. A disturbed antimicrobial defense as provided by an arsenal of different epithelial defensins seems to be a critical factor in disease pathogenesis. Defensins are antimicrobial peptides and in the ileum are mainly expressed in Paneth cells (PCs), epithelial cells that also express NOD2 . In the colon, defensins are expressed by enterocytes or metaplastic PCs. Ileal CD patients are characterized by a reduced antibacterial activity and a specific reduction of ileal PC defensins. In ileal Crohn's patients displaying a NOD2 mutation, this decrease is even more pronounced. In contrast, CD of the colon is characterized by an impaired induction of beta defensins in enterocytes. In conclusion, the regional localizations of CD, either ileal or colonic disease, can be linked to different defects in defensin expression. In line with these new findings, we predict that future therapeutic strategies aimed at restoring the host–microbe balance at the intestinal mucosa may prove superior to those that broadly suppress inflammation and adaptive immunity." @default.
• W2010713573 created "2016-06-24" @default.
• W2010713573 creator A5029630686 @default.
• W2010713573 creator A5080773158 @default.
• W2010713573 date "2006-08-01" @default.
• W2010713573 modified "2023-10-15" @default.
• W2010713573 title "A New Look at Crohn's Disease" @default.
• W2010713573 cites W1571292455 @default.
• W2010713573 cites W1608815389 @default.
• W2010713573 cites W1642457845 @default.
• W2010713573 cites W1670573097 @default.
• W2010713573 cites W1972672220 @default.
• W2010713573 cites W1979859398 @default.
• W2010713573 cites W1991625690 @default.
• W2010713573 cites W1993458743 @default.
• W2010713573 cites W1997942004 @default.
• W2010713573 cites W1998395322 @default.
• W2010713573 cites W2000931665 @default.
• W2010713573 cites W2002211351 @default.
• W2010713573 cites W2009706335 @default.
• W2010713573 cites W2032221835 @default.
• W2010713573 cites W2038343076 @default.
• W2010713573 cites W2040780867 @default.
• W2010713573 cites W2042481588 @default.
• W2010713573 cites W2043667001 @default.
• W2010713573 cites W2054602599 @default.
• W2010713573 cites W2057198053 @default.
• W2010713573 cites W2060300255 @default.
• W2010713573 cites W2066754670 @default.
• W2010713573 cites W2075328959 @default.
• W2010713573 cites W2075345118 @default.
• W2010713573 cites W2077604052 @default.
• W2010713573 cites W2087028779 @default.
• W2010713573 cites W2090042814 @default.
• W2010713573 cites W2095464081 @default.
• W2010713573 cites W2097121808 @default.
• W2010713573 cites W2100305071 @default.
• W2010713573 cites W2105579244 @default.
• W2010713573 cites W2110521139 @default.
• W2010713573 cites W2115360262 @default.
• W2010713573 cites W2131691027 @default.
• W2010713573 cites W2134935858 @default.
• W2010713573 cites W2135100507 @default.
• W2010713573 cites W2146994866 @default.
• W2010713573 cites W2153328681 @default.
• W2010713573 cites W2153905079 @default.
• W2010713573 cites W2158364865 @default.
• W2010713573 cites W2158789628 @default.
• W2010713573 cites W2161215353 @default.
• W2010713573 cites W2163665267 @default.
• W2010713573 cites W2169909966 @default.
• W2010713573 cites W2773388190 @default.
• W2010713573 cites W4292198229 @default.
• W2010713573 cites W4313309903 @default.
• W2010713573 doi "https://doi.org/10.1196/annals.1326.030" @default.
• W2010713573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17057212" @default.
• W2010713573 hasPublicationYear "2006" @default.
• W2010713573 type Work @default.
• W2010713573 sameAs 2010713573 @default.
• W2010713573 citedByCount "60" @default.
• W2010713573 countsByYear W20107135732012 @default.
• W2010713573 countsByYear W20107135732013 @default.
• W2010713573 countsByYear W20107135732015 @default.
• W2010713573 countsByYear W20107135732016 @default.
• W2010713573 countsByYear W20107135732017 @default.
• W2010713573 countsByYear W20107135732019 @default.
• W2010713573 countsByYear W20107135732021 @default.
• W2010713573 countsByYear W20107135732022 @default.
• W2010713573 crossrefType "journal-article" @default.
• W2010713573 hasAuthorship W2010713573A5029630686 @default.
• W2010713573 hasAuthorship W2010713573A5080773158 @default.
• W2010713573 hasConcept C126322002 @default.
• W2010713573 hasConcept C129437159 @default.
• W2010713573 hasConcept C142724271 @default.
• W2010713573 hasConcept C203014093 @default.
• W2010713573 hasConcept C2776145723 @default.
• W2010713573 hasConcept C2776498113 @default.
• W2010713573 hasConcept C2776914184 @default.
• W2010713573 hasConcept C2777226302 @default.
• W2010713573 hasConcept C2777882243 @default.
• W2010713573 hasConcept C2778260677 @default.
• W2010713573 hasConcept C2779134260 @default.
• W2010713573 hasConcept C2779280984 @default.
• W2010713573 hasConcept C2780942790 @default.
• W2010713573 hasConcept C4937899 @default.
• W2010713573 hasConcept C540938839 @default.
• W2010713573 hasConcept C71924100 @default.
• W2010713573 hasConcept C7573103 @default.
• W2010713573 hasConcept C86803240 @default.
• W2010713573 hasConcept C89423630 @default.
• W2010713573 hasConceptScore W2010713573C126322002 @default.
• W2010713573 hasConceptScore W2010713573C129437159 @default.
• W2010713573 hasConceptScore W2010713573C142724271 @default.
• W2010713573 hasConceptScore W2010713573C203014093 @default.
• W2010713573 hasConceptScore W2010713573C2776145723 @default.
• W2010713573 hasConceptScore W2010713573C2776498113 @default.
• W2010713573 hasConceptScore W2010713573C2776914184 @default.
• W2010713573 hasConceptScore W2010713573C2777226302 @default.

• next