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• W2010741354 abstract "Solid tumors must recruit and form new blood vessels for maintenance, growth and detachments of metastases. Discovering drugs that block malignant angiogenesis is thus an important approach in cancer treatment and has given rise to multiple in vitro and in silico models. The present hybrid individual cell-based model incorporates some underlying biochemical events relating more closely the classical Cellular Potts Model (CPM) parameters to subcellular mechanisms and to the activation of specific signaling pathways. The model spans the three fundamental biological levels: at the extracellular level a continuous model describes secretion, diffusion, uptake and decay of the autocrine VEGF; at the cellular level, an extended lattice CPM, based on a system energy reduction, reproduces cell dynamics such as migration, adhesion and chemotaxis; at the subcellular level, a set of reaction-diffusion equations describes a simplified VEGF-induced calcium-dependent intracellular pathway. The results agree with the known interplay between calcium signals and VEGF dynamics and with their role in malignant vasculogenesis. Moreover, the analysis of the link between the microscopic subcellular dynamics and the macroscopic cell behaviors confirms the efficiency of some pharmacological interventions that are currently in use and, more interestingly, proposes some new therapeutic approaches, that are counter-intuitive but potentially effective." @default.
• W2010741354 created "2016-06-24" @default.
• W2010741354 creator A5003500970 @default.
• W2010741354 creator A5059836069 @default.
• W2010741354 creator A5068040288 @default.
• W2010741354 date "2011-08-01" @default.
• W2010741354 modified "2023-09-27" @default.
• W2010741354 title "A multiscale hybrid approach for vasculogenesis and related potential blocking therapies" @default.
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• W2010741354 doi "https://doi.org/10.1016/j.pbiomolbio.2011.01.004" @default.
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