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- W2010742973 abstract "Serum GH levels in untreated rats were found to increase spontaneously to over 300 ng/ml around the onset of darkness (1900 h) and then decrease to under 100 ng/ml by 2000 h. Pretreatment with the serotonin receptor blockers, metergoline (0.2, 0.5, 1, or 2 mg/kg) or cyproheptadine (1, 2, or 5 mg/kg), at 1800 h significantly blunted this physiological rise in serum GH. In rats bearing chronic right atrial cannulae from which blood samples were drawn every 15 min for 5 h, the administration of metergoline (1 mg/kg) was also observed to reduce plasma GH levels over a 3.25-h period. Serotonin-containing neurons in the brain thus seem to be involved in the physiological secretion of GH." @default.
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- W2010742973 date "1978-10-01" @default.
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- W2010742973 title "Serotonin Receptor Antagonists Block a Natural, Short Term Surge in Serum Growth Hormone Levels*" @default.
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- W2010742973 doi "https://doi.org/10.1210/endo-103-4-1159" @default.
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