Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010744168> ?p ?o ?g. }
- W2010744168 endingPage "213" @default.
- W2010744168 startingPage "207" @default.
- W2010744168 abstract "Disease-causing mutations in the amyloid precursor protein (APP) gene have been found on chromosome 21 during the last 2 years in some early onset Alzheimer's disease (AD) families. Genetic evidence shows that other genes than the APP are also involved in the aetiology of AD. Linkage to a loci on chromosome 14 has been found in early onset disease. The identification of APP mutation has led to the realization that APP mismetabolism is a central event in the aetiology and pathogenesis of the disease. Experiments to test this in transgenic mice have so far met with little success. There are many possible explanations for the problems to generate transgenic mice. These include the possibilities that mice are incapable of developing AD for reasons dependent on their APP sequence; and that appropriate regulation of APP gene is required for pathology to develop. Current attempts that seem promising to model the disease pathology are the use of homologous recombination to insert the pathogenic mutation and transfection of YACs into transgenic animals." @default.
- W2010744168 created "2016-06-24" @default.
- W2010744168 creator A5002497913 @default.
- W2010744168 creator A5006563536 @default.
- W2010744168 creator A5018345023 @default.
- W2010744168 creator A5020514779 @default.
- W2010744168 creator A5023833947 @default.
- W2010744168 creator A5029554560 @default.
- W2010744168 creator A5081283156 @default.
- W2010744168 date "1993-11-01" @default.
- W2010744168 modified "2023-09-30" @default.
- W2010744168 title "Alzheimer's disease: Molecular genetics and transgenic animal models" @default.
- W2010744168 cites W1482407471 @default.
- W2010744168 cites W1511379621 @default.
- W2010744168 cites W1969810313 @default.
- W2010744168 cites W1970620640 @default.
- W2010744168 cites W1977809930 @default.
- W2010744168 cites W1982236659 @default.
- W2010744168 cites W1985964521 @default.
- W2010744168 cites W1986199494 @default.
- W2010744168 cites W1990793673 @default.
- W2010744168 cites W1993969806 @default.
- W2010744168 cites W2000222141 @default.
- W2010744168 cites W2007317812 @default.
- W2010744168 cites W2012862084 @default.
- W2010744168 cites W2013873450 @default.
- W2010744168 cites W2020460543 @default.
- W2010744168 cites W2022446410 @default.
- W2010744168 cites W2022907394 @default.
- W2010744168 cites W2024363942 @default.
- W2010744168 cites W2024945039 @default.
- W2010744168 cites W2027009747 @default.
- W2010744168 cites W2029676983 @default.
- W2010744168 cites W2030641075 @default.
- W2010744168 cites W2031129820 @default.
- W2010744168 cites W2033356439 @default.
- W2010744168 cites W2036288989 @default.
- W2010744168 cites W2036642860 @default.
- W2010744168 cites W2047819219 @default.
- W2010744168 cites W2051745417 @default.
- W2010744168 cites W2054353872 @default.
- W2010744168 cites W2058723245 @default.
- W2010744168 cites W2064093411 @default.
- W2010744168 cites W2064798015 @default.
- W2010744168 cites W2069682857 @default.
- W2010744168 cites W2070536520 @default.
- W2010744168 cites W2072296425 @default.
- W2010744168 cites W2073806885 @default.
- W2010744168 cites W2076384868 @default.
- W2010744168 cites W2076693005 @default.
- W2010744168 cites W2077859295 @default.
- W2010744168 cites W2081133904 @default.
- W2010744168 cites W2081569845 @default.
- W2010744168 cites W2081881251 @default.
- W2010744168 cites W2084149528 @default.
- W2010744168 cites W2084972185 @default.
- W2010744168 cites W2086278983 @default.
- W2010744168 cites W2090150925 @default.
- W2010744168 cites W2090390963 @default.
- W2010744168 cites W2090446966 @default.
- W2010744168 cites W2090601883 @default.
- W2010744168 cites W2094581250 @default.
- W2010744168 cites W2095005214 @default.
- W2010744168 cites W2095018549 @default.
- W2010744168 cites W2103440561 @default.
- W2010744168 cites W212267014 @default.
- W2010744168 cites W2133580965 @default.
- W2010744168 cites W2332068507 @default.
- W2010744168 cites W2405724104 @default.
- W2010744168 doi "https://doi.org/10.1016/0166-4328(93)90137-f" @default.
- W2010744168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8117426" @default.
- W2010744168 hasPublicationYear "1993" @default.
- W2010744168 type Work @default.
- W2010744168 sameAs 2010744168 @default.
- W2010744168 citedByCount "21" @default.
- W2010744168 countsByYear W20107441682012 @default.
- W2010744168 countsByYear W20107441682013 @default.
- W2010744168 countsByYear W20107441682014 @default.
- W2010744168 countsByYear W20107441682019 @default.
- W2010744168 countsByYear W20107441682022 @default.
- W2010744168 crossrefType "journal-article" @default.
- W2010744168 hasAuthorship W2010744168A5002497913 @default.
- W2010744168 hasAuthorship W2010744168A5006563536 @default.
- W2010744168 hasAuthorship W2010744168A5018345023 @default.
- W2010744168 hasAuthorship W2010744168A5020514779 @default.
- W2010744168 hasAuthorship W2010744168A5023833947 @default.
- W2010744168 hasAuthorship W2010744168A5029554560 @default.
- W2010744168 hasAuthorship W2010744168A5081283156 @default.
- W2010744168 hasConcept C102230213 @default.
- W2010744168 hasConcept C104317684 @default.
- W2010744168 hasConcept C137555145 @default.
- W2010744168 hasConcept C141035611 @default.
- W2010744168 hasConcept C142724271 @default.
- W2010744168 hasConcept C175344181 @default.
- W2010744168 hasConcept C203014093 @default.
- W2010744168 hasConcept C2779134260 @default.
- W2010744168 hasConcept C2780942790 @default.
- W2010744168 hasConcept C30481170 @default.