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- W2010745908 abstract "Protein secretion from acinar cells of the pancreas and parotid glands is controlled by G-protein coupled receptor activation and generation of the cellular messengers Ca2+, diacylglycerol and cAMP. Secretory granule (SG) exocytosis shares some common characteristics with nerve, neuroendocrine and endocrine cells which are regulated mainly by elevated cell Ca2+. However, in addition to diverse signaling pathways, acinar cells have large ∼1 μm diameter SGs (∼30 fold larger diameter than synaptic vesicles), respond to stimulation at slower rates (seconds versus milliseconds), demonstrate significant constitutive secretion, and in isolated acini, undergo sequential compound SG–SG exocytosis at the apical membrane. Exocytosis proceeds as an initial rapid phase that peaks and declines over 3 min followed by a prolonged phase that decays to near basal levels over 20–30 min. Studies indicate the early phase is triggered by Ca2+ and involves the SG proteins VAMP2 (vesicle associated membrane protein2), Ca2+-sensing protein synatotagmin 1 (syt1) and the accessory protein complexin 2. The molecular details for regulation of VAMP8-mediated SG exocytosis and the prolonged phase of secretion are still emerging. Here we review the known regulatory molecules that impact the sequential exocytic process of SG tethering, docking, priming and fusion in acinar cells." @default.
- W2010745908 created "2016-06-24" @default.
- W2010745908 creator A5047680168 @default.
- W2010745908 creator A5062169330 @default.
- W2010745908 creator A5082812084 @default.
- W2010745908 date "2014-06-01" @default.
- W2010745908 modified "2023-10-07" @default.
- W2010745908 title "Ca2+-regulated secretory granule exocytosis in pancreatic and parotid acinar cells" @default.
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- W2010745908 doi "https://doi.org/10.1016/j.ceca.2014.03.003" @default.
- W2010745908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4058401" @default.
- W2010745908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24742357" @default.
- W2010745908 hasPublicationYear "2014" @default.
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