FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010747015> ?p ?o ?g. }

• W2010747015 endingPage "97" @default.
• W2010747015 startingPage "90" @default.
• W2010747015 abstract "Repeated administration of non-competitive N-methyl-d-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) to rodents causes long-lasting deficits in cognition and memory, and has effects on behaviors that have been suggested to be models of the cognitive impairment associated with schizophrenia (CIAS). Despite this being a widely studied animal model, little is known about the long lasting changes in synapses and circuits that underlie the altered behaviors. Here we examined synaptic transmission ex-vivo in the hippocampus of mice after a subchronic PCP (scPCP) administration regime. We found that after at least one week of drug free washout period when mice have impaired cognitive function, the threshold for long-term potentiation (LTP) of CA1 excitatory synapses was elevated. This elevated LTP threshold was directly related to increased inhibitory input to CA1 pyramidal cells through increased activity of GABAergic neurons. These results suggest repeated PCP administration causes a long-lasting metaplastic change in the inhibitory circuits in the hippocampus that results in impaired LTP, and could contribute to the deficits in hippocampal-dependent memory in PCP-treated mice. Changes in GABA signaling have been described in patients with schizophrenia, therefore our results support using scPCP as a model of CIAS. This article is part of the Special Issue entitled 'Synaptopathy--from Biology to Therapy'." @default.
• W2010747015 created "2016-06-24" @default.
• W2010747015 creator A5004294961 @default.
• W2010747015 creator A5021625959 @default.
• W2010747015 creator A5023524045 @default.
• W2010747015 creator A5059938833 @default.
• W2010747015 creator A5060728653 @default.
• W2010747015 creator A5079864851 @default.
• W2010747015 creator A5088060910 @default.
• W2010747015 date "2016-01-01" @default.
• W2010747015 modified "2023-09-28" @default.
• W2010747015 title "Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus" @default.
• W2010747015 cites W1616286551 @default.
• W2010747015 cites W1802920408 @default.
• W2010747015 cites W1872072116 @default.
• W2010747015 cites W1969369006 @default.
• W2010747015 cites W1982487023 @default.
• W2010747015 cites W1983578309 @default.
• W2010747015 cites W1983719168 @default.
• W2010747015 cites W1986336245 @default.
• W2010747015 cites W1995079626 @default.
• W2010747015 cites W1995620695 @default.
• W2010747015 cites W2002764325 @default.
• W2010747015 cites W2009309964 @default.
• W2010747015 cites W2013542473 @default.
• W2010747015 cites W2015205118 @default.
• W2010747015 cites W2018283369 @default.
• W2010747015 cites W2018415267 @default.
• W2010747015 cites W2019363012 @default.
• W2010747015 cites W2020326582 @default.
• W2010747015 cites W2026782090 @default.
• W2010747015 cites W2031272002 @default.
• W2010747015 cites W2034779270 @default.
• W2010747015 cites W2036691985 @default.
• W2010747015 cites W2039242920 @default.
• W2010747015 cites W2046004431 @default.
• W2010747015 cites W2052262915 @default.
• W2010747015 cites W2058889376 @default.
• W2010747015 cites W2062030838 @default.
• W2010747015 cites W2066287357 @default.
• W2010747015 cites W2072093845 @default.
• W2010747015 cites W2073239561 @default.
• W2010747015 cites W2075187431 @default.
• W2010747015 cites W2083718947 @default.
• W2010747015 cites W2084017889 @default.
• W2010747015 cites W2090246683 @default.
• W2010747015 cites W2106419157 @default.
• W2010747015 cites W2110652090 @default.
• W2010747015 cites W2121398326 @default.
• W2010747015 cites W2125648698 @default.
• W2010747015 cites W2126407771 @default.
• W2010747015 cites W2126843605 @default.
• W2010747015 cites W2132951361 @default.
• W2010747015 cites W2141787834 @default.
• W2010747015 cites W2148049102 @default.
• W2010747015 cites W2151856267 @default.
• W2010747015 cites W2156286194 @default.
• W2010747015 cites W2171865323 @default.
• W2010747015 doi "https://doi.org/10.1016/j.neuropharm.2015.04.012" @default.
• W2010747015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4584174" @default.
• W2010747015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25937215" @default.
• W2010747015 hasPublicationYear "2016" @default.
• W2010747015 type Work @default.
• W2010747015 sameAs 2010747015 @default.
• W2010747015 citedByCount "34" @default.
• W2010747015 countsByYear W20107470152015 @default.
• W2010747015 countsByYear W20107470152016 @default.
• W2010747015 countsByYear W20107470152017 @default.
• W2010747015 countsByYear W20107470152018 @default.
• W2010747015 countsByYear W20107470152019 @default.
• W2010747015 countsByYear W20107470152020 @default.
• W2010747015 countsByYear W20107470152021 @default.
• W2010747015 countsByYear W20107470152022 @default.
• W2010747015 crossrefType "journal-article" @default.
• W2010747015 hasAuthorship W2010747015A5004294961 @default.
• W2010747015 hasAuthorship W2010747015A5021625959 @default.
• W2010747015 hasAuthorship W2010747015A5023524045 @default.
• W2010747015 hasAuthorship W2010747015A5059938833 @default.
• W2010747015 hasAuthorship W2010747015A5060728653 @default.
• W2010747015 hasAuthorship W2010747015A5079864851 @default.
• W2010747015 hasAuthorship W2010747015A5088060910 @default.
• W2010747015 hasBestOaLocation W20107470152 @default.
• W2010747015 hasConcept C112592302 @default.
• W2010747015 hasConcept C118552586 @default.
• W2010747015 hasConcept C126322002 @default.
• W2010747015 hasConcept C148762608 @default.
• W2010747015 hasConcept C15744967 @default.
• W2010747015 hasConcept C169760540 @default.
• W2010747015 hasConcept C170493617 @default.
• W2010747015 hasConcept C17077164 @default.
• W2010747015 hasConcept C200170125 @default.
• W2010747015 hasConcept C25274449 @default.
• W2010747015 hasConcept C2776412080 @default.
• W2010747015 hasConcept C2778851735 @default.
• W2010747015 hasConcept C2779177108 @default.
• W2010747015 hasConcept C2781161787 @default.
• W2010747015 hasConcept C67018056 @default.
• W2010747015 hasConcept C71924100 @default.

• next