FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010747883> ?p ?o ?g. }

• W2010747883 endingPage "5557" @default.
• W2010747883 startingPage "5549" @default.
• W2010747883 abstract "GnRH analog (GnRHa) and TGF-beta act directly on leiomyoma/myometrial smooth muscle cells (LSMCs and MSMCs) regulating diverse activities resulting in leiomyoma growth and regression. Because GnRH and TGF-beta receptor signaling is in part mediated through the MAPK pathway, we determined whether the contribution of MAPK/ERK and transcriptional activation of c-fos and c-jun, result in differential regulation of type I collagen, fibronectin, and plasminogen activator inhibitor 1 (PAI-1) gene expression, whose products are known to influence extracellular matrix turnover, which is critical in leiomyoma growth and GnRHa-induced regression. We found that GnRHa and TGF-beta in a dose- and time-dependent manner increased the level of phosphorylated ERK1/2 (pERK1/2) in LSMCs and MSMCs. GnRHa and TGF-beta increased ERK1/2 nuclear accumulation resulting in differential regulation of c-fos and c-jun mRNA expression via downstream signaling from MAPK kinase (MEK)1/2, because pretreatment with U0126, a synthetic inhibitor of MEK1/2, abolished basal and GnRHa- and TGF-beta-induced pERK1/2 and the expression of c-fos and c-jun. LSMCs and MSMCs also express fibronectin, type I collagen, and PAI-1 mRNA, and GnRHa and TGF-beta altered their expression in a cell-specific manner through MEK1/2. We concluded that GnRHa and TGF-beta acting through a MAPK/ERK pathway and transcriptional activation of c-fos/c-jun results in differential regulation of specific genes whose products may in part influence the outcome of leiomyoma growth and regression." @default.
• W2010747883 created "2016-06-24" @default.
• W2010747883 creator A5031138425 @default.
• W2010747883 creator A5042346357 @default.
• W2010747883 creator A5049396596 @default.
• W2010747883 creator A5089783895 @default.
• W2010747883 date "2004-11-01" @default.
• W2010747883 modified "2023-09-25" @default.
• W2010747883 title "Gonadotropin Releasing Hormone and Transforming Growth Factor β Activate Mitogen-Activated Protein Kinase/Extracellularly Regulated Kinase and Differentially Regulate Fibronectin, Type I Collagen, and Plasminogen Activator Inhibitor-1 Expression in Leiomyoma and Myometrial Smooth Muscle Cells" @default.
• W2010747883 cites W1526021984 @default.
• W2010747883 cites W1976875374 @default.
• W2010747883 cites W1979683683 @default.
• W2010747883 cites W2011463663 @default.
• W2010747883 cites W2013444999 @default.
• W2010747883 cites W2013821069 @default.
• W2010747883 cites W2022321394 @default.
• W2010747883 cites W2022779155 @default.
• W2010747883 cites W2029222193 @default.
• W2010747883 cites W2029937779 @default.
• W2010747883 cites W2030148120 @default.
• W2010747883 cites W2030872161 @default.
• W2010747883 cites W2031118736 @default.
• W2010747883 cites W2035482668 @default.
• W2010747883 cites W2037647353 @default.
• W2010747883 cites W2037872261 @default.
• W2010747883 cites W2038101078 @default.
• W2010747883 cites W2042241941 @default.
• W2010747883 cites W2042289154 @default.
• W2010747883 cites W2043136148 @default.
• W2010747883 cites W2047633774 @default.
• W2010747883 cites W2053223614 @default.
• W2010747883 cites W2057621218 @default.
• W2010747883 cites W2061929388 @default.
• W2010747883 cites W2064600196 @default.
• W2010747883 cites W2070371187 @default.
• W2010747883 cites W2073500252 @default.
• W2010747883 cites W2079475371 @default.
• W2010747883 cites W2081163324 @default.
• W2010747883 cites W2086262311 @default.
• W2010747883 cites W2087214723 @default.
• W2010747883 cites W2093531115 @default.
• W2010747883 cites W2100196866 @default.
• W2010747883 cites W2103414302 @default.
• W2010747883 cites W2108144590 @default.
• W2010747883 cites W2112964135 @default.
• W2010747883 cites W2125746812 @default.
• W2010747883 cites W2128606678 @default.
• W2010747883 cites W2133193835 @default.
• W2010747883 cites W2133958768 @default.
• W2010747883 cites W2137334457 @default.
• W2010747883 cites W2137676124 @default.
• W2010747883 cites W2154568166 @default.
• W2010747883 cites W2155269388 @default.
• W2010747883 cites W2165709407 @default.
• W2010747883 cites W2170933176 @default.
• W2010747883 cites W2316067769 @default.
• W2010747883 cites W2413820230 @default.
• W2010747883 cites W359659477 @default.
• W2010747883 cites W92111337 @default.
• W2010747883 doi "https://doi.org/10.1210/jc.2004-0161" @default.
• W2010747883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15531510" @default.
• W2010747883 hasPublicationYear "2004" @default.
• W2010747883 type Work @default.
• W2010747883 sameAs 2010747883 @default.
• W2010747883 citedByCount "70" @default.
• W2010747883 countsByYear W20107478832012 @default.
• W2010747883 countsByYear W20107478832013 @default.
• W2010747883 countsByYear W20107478832014 @default.
• W2010747883 countsByYear W20107478832015 @default.
• W2010747883 countsByYear W20107478832016 @default.
• W2010747883 countsByYear W20107478832017 @default.
• W2010747883 countsByYear W20107478832018 @default.
• W2010747883 countsByYear W20107478832019 @default.
• W2010747883 countsByYear W20107478832020 @default.
• W2010747883 countsByYear W20107478832021 @default.
• W2010747883 countsByYear W20107478832022 @default.
• W2010747883 crossrefType "journal-article" @default.
• W2010747883 hasAuthorship W2010747883A5031138425 @default.
• W2010747883 hasAuthorship W2010747883A5042346357 @default.
• W2010747883 hasAuthorship W2010747883A5049396596 @default.
• W2010747883 hasAuthorship W2010747883A5089783895 @default.
• W2010747883 hasBestOaLocation W20107478831 @default.
• W2010747883 hasConcept C126322002 @default.
• W2010747883 hasConcept C134018914 @default.
• W2010747883 hasConcept C170493617 @default.
• W2010747883 hasConcept C184235292 @default.
• W2010747883 hasConcept C185592680 @default.
• W2010747883 hasConcept C189165786 @default.
• W2010747883 hasConcept C2779679481 @default.
• W2010747883 hasConcept C2780675426 @default.
• W2010747883 hasConcept C57074206 @default.
• W2010747883 hasConcept C62478195 @default.
• W2010747883 hasConcept C71924100 @default.
• W2010747883 hasConcept C86492073 @default.
• W2010747883 hasConcept C86803240 @default.
• W2010747883 hasConcept C88045685 @default.
• W2010747883 hasConcept C95444343 @default.
• W2010747883 hasConcept C97029542 @default.

• next